Lithium Chloride (CAS 7447-41-8)
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Lithium Chloride is an antiviral metal halide utilized in a variety of assays to study cell-fate and neurobiology. In developing Xenopus embryos, lithium chloride is observed to exert inhibition of GSK-3beta (glycogen synthase kinase-3beta), yet not reported to be a general inhibitor of other protein kinases. These observations may have implications for lithium chloride on cell-fate determination in several organisms including Xenopus and Dictyostelium. Additionally, in transfected Chinese Hamster Ovary cells (CHO) stimulated with angiotension II (Ang II), it was noted that lithium chloride enhanced the production of inositol triphosphate. The antiviral properties of lithium chloride were noted in a study which showed that the compound inhibited pseudorabis virus infection in vitro. In Drosophila, it was observed that in the nervous system, lithium chloride may have an effect on amino acid metabolism. Futhermore, in glial primary cell cultures, lithium chloride has been noted to provide protection against glutamate excitotoxicity by potentially reducing NR1 mRNA, the major N-methyl-D-aspartate receptor (NMDAR) subunit in the cells.
Lithium Chloride (CAS 7447-41-8) References
- Combination therapy with histone deacetylase inhibitors and lithium chloride: a novel treatment for carcinoid tumors. | Adler, JT., et al. 2009. Ann Surg Oncol. 16: 481-6. PMID: 19030935
- Lithium chloride protects retinal neurocytes from nutrient deprivation by promoting DNA non-homologous end-joining. | Zhuang, J., et al. 2009. Biochem Biophys Res Commun. 380: 650-4. PMID: 19285016
- Effects of lithium chloride on the gene expression profiles in Drosophila heads. | Kasuya, J., et al. 2009. Neurosci Res. 64: 413-20. PMID: 19410610
- Antiviral effect of diammonium glycyrrhizinate and lithium chloride on cell infection by pseudorabies herpesvirus. | Sui, X., et al. 2010. Antiviral Res. 85: 346-53. PMID: 19879899
- Lithium chloride prevents interleukin-1β induced cartilage degradation and loss of mechanical properties. | Thompson, CL., et al. 2015. J Orthop Res. 33: 1552-9. PMID: 26174175
- Lithium chloride assuages bone loss in experimental periodontitis in estrogen-deficient rats. | de Souza Malta, F., et al. 2020. Clin Oral Investig. 24: 2025-2036. PMID: 31512073
- Lithium chloride ameliorates cognition dysfunction induced by sevoflurane anesthesia in rats. | Wang, Y., et al. 2020. FEBS Open Bio. 10: 251-258. PMID: 31867790
- Lithium chloride outperformed oxalic acid sublimation in a preliminary experiment for Varroa mite control in pre-wintering honey bee colonies. | Kolics, É., et al. 2021. Acta Vet Hung. 68: 370-373. PMID: 33459613
- Lithium chloride inhibits infectious bronchitis virus-induced apoptosis and inflammation. | Liu, X., et al. 2022. Microb Pathog. 162: 105352. PMID: 34883226
- Lithium chloride-induced primary cilia recovery enhances biosynthetic response of chondrocytes to mechanical stimulation. | Soave, A., et al. 2022. Biomech Model Mechanobiol. 21: 605-614. PMID: 35091857
- Baicalin Coadministration with Lithium Chloride Enhanced Neurogenesis via GSK3β Pathway in Corticosterone Induced PC-12 Cells. | Wang, Z., et al. 2022. Biol Pharm Bull. 45: 605-613. PMID: 35296580
- Aqueous lithium chloride solution as a non-toxic bactericidal and fungicidal disinfectant for air-conditioning systems: Efficacy and mechanism. | Gu, Y., et al. 2022. Environ Res. 212: 113112. PMID: 35346655
- Effect of lithium chloride on food intake, cloacal temperature, voluntary activity, and crop-emptying rate in chicks. | Tachibana, T., et al. 2022. Comp Biochem Physiol A Mol Integr Physiol. 273: 111284. PMID: 35918017
- A molecular mechanism for the effect of lithium on development. | Klein, PS. and Melton, DA. 1996. Proc Natl Acad Sci U S A. 93: 8455-9. PMID: 8710892
- Use of LiCl in phospholipase C assays masks the impaired functionality of a mutant angiotensin II receptor. | Chrétien, L., et al. 1997. Cell Signal. 9: 379-82. PMID: 9376218
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lithium Chloride, 50 g | sc-203110 | 50 g | $33.00 | |||
Lithium Chloride, 250 g | sc-203110A | 250 g | $110.00 | |||
Lithium Chloride, 1 kg | sc-203110B | 1 kg | $265.00 | |||
Lithium Chloride, 2.5 kg | sc-203110C | 2.5 kg | $500.00 | |||
Lithium Chloride, 5 kg | sc-203110D | 5 kg | $950.00 | |||
Lithium Chloride, 10 kg | sc-203110E | 10 kg | $1487.00 |