OR3A2 Activators
Forskolin stands out as a direct stimulant of adenylate cyclase, leading to an upsurge in cAMP levels, which activates PKA. This kinase can phosphorylate a range of cellular proteins, potentially altering OR3A2 activity. Similarly, IBMX sustains cAMP levels by inhibiting phosphodiesterases, which indirectly supports the activation of PKA, again influencing OR3A2. The calcium ionophores Ionomycin and A23187 elevate intracellular calcium, which activates calcium-dependent kinases that could potentially modulate OR3A2. Moreover, PMA activates PKC, with a broad range of targets that may include pathways involving OR3A2. On a different note, LY294002, U0126, and PD98059 interfere with PI3K/AKT and MAPK/ERK pathways respectively, which are crucial in regulating cellular activities, including those related to OR3A2.
Genistein, by inhibiting tyrosine kinases, impacts phosphorylation cascades that can influence the activity of proteins such as OR3A2. In contrast, Okadaic Acid and Calyculin A inhibit phosphatases like PP1 and PP2A, causing an increase in the phosphorylation state of proteins, which may shift the balance towards OR3A2 activation. Anisomycin, though primarily a protein synthesis inhibitor, activates stress-activated protein kinases, potentially affecting OR3A2 activity as part of the cellular stress response.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate various targets within the cell, thereby modulating their activity and can lead to the activation of OR3A2. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX acts as a non-selective inhibitor of phosphodiesterases, enzymes that degrade cAMP. By preventing cAMP breakdown, IBMX indirectly maintains higher levels of intracellular cAMP, which can enhance PKA activity and promote the activation of OR3A2. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinases, which in turn can influence various signaling pathways and proteins, including OR3A2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can phosphorylate a wide range of target proteins. PKC activation can potentially modulate signaling pathways associated with OR3A2. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, it can alter the AKT signaling pathway, which regulates numerous cellular processes that can include the modulation of proteins like OR3A2. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of mitogen-activated protein kinase kinase (MEK), which is part of the MAPK/ERK pathway. Inhibition of this pathway can lead to changes in protein activities and cellular responses, potentially including the activation of OR3A2. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is another MEK inhibitor, functioning similarly to U0126, by altering the MAPK/ERK pathway and affecting downstream protein activity that may be related to OR3A2 activation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can impact phosphorylation cascades. By modulating tyrosine kinase activity, it can influence signaling pathways and affect protein functions that include the activation of OR3A2. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore like ionomycin and also increases intracellular calcium levels, which can trigger various calcium-dependent signaling mechanisms potentially involved in OR3A2 activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is an inhibitor of protein phosphatases PP1 and PP2A. Inhibition of these phosphatases can lead to increased phosphorylation levels of cellular proteins, influencing signaling pathways and possibly leading to OR3A2 activation. | ||||||