OPA3 Inhibitors
OPA3 inhibitors are a class of chemical compounds that target the OPA3 protein, an inner mitochondrial membrane protein implicated in various biochemical processes. OPA3 is believed to play a role in maintaining mitochondrial integrity and function, particularly in relation to energy metabolism and oxidative stress regulation. The inhibition of OPA3 disrupts its normal interaction with mitochondrial membranes, which can lead to alterations in mitochondrial dynamics such as fission and fusion processes. Mitochondria, being critical for ATP production and the regulation of cellular homeostasis, are highly sensitive to these changes, leading to downstream effects on metabolic pathways. In particular, OPA3 inhibitors can influence processes like fatty acid oxidation, respiratory chain activity, and the handling of reactive oxygen species (ROS) within the mitochondria.
The molecular mechanisms through which OPA3 inhibitors act involve binding to specific sites on the OPA3 protein, leading to allosteric changes or direct occlusion of active sites. These inhibitors may affect mitochondrial permeability and contribute to altered membrane potential, which is crucial for ATP synthesis and ion transport. The downstream effects on cellular energy balance can also influence pathways such as apoptosis, cellular stress responses, and metabolic adaptations. Research into OPA3 inhibitors is ongoing to better understand how these compounds interact with mitochondrial biology, particularly in how they can modulate energy production, influence oxidative stress responses, and potentially alter mitochondrial morphology and function. The biophysical and biochemical characteristics of OPA3 inhibitors remain a growing field of study, with implications for understanding mitochondrial-related processes at the molecular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $70.00 $282.00 | 6 | |
2-Methoxyestradiol inhibits HIF-1α, which is involved in the regulation of mitochondrial dynamics and biogenesis. Since OPA3 is associated with mitochondrial function and morphology, the inhibition of HIF-1α can lead to altered mitochondrial dynamics, thereby functionally inhibiting OPA3 activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein inhibits tyrosine kinases, which are involved in the signaling pathways that regulate mitochondrial function and apoptosis. By inhibiting these kinases, Genistein can disrupt the signaling required for maintaining mitochondrial integrity, where OPA3 plays a crucial role. | ||||||
Decylubiquinone | 55486-00-5 | sc-358659 sc-358659A | 10 mg 50 mg | $69.00 $260.00 | 10 | |
Decylubiquinone acts as an inhibitor of mitochondrial electron transport chain at complex I and II, which OPA3 may influence due to its mitochondrial localization. Inhibiting the electron transport chain can impair mitochondrial function, indirectly inhibiting OPA3's role in maintaining mitochondrial health. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Oligomycin inhibits ATP synthase in mitochondria. Since OPA3 is involved in maintaining mitochondrial health, the inhibition of ATP production can lead to a dysfunction of mitochondria, which would functionally inhibit the activity of OPA3. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A inhibits cytochrome c reductase in the mitochondrial electron transport chain. Disruption of this chain can lead to mitochondrial dysfunction, which would affect OPA3 due to its role in mitochondrial morphology and function. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is an inhibitor of mitochondrial complex I. By inhibiting this complex, it leads to mitochondrial dysfunction and potential disruption of processes that OPA3 is involved in, particularly mitochondrial maintenance and function. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $36.00 | 1 | |
Thenoyltrifluoroacetone (TTFA) is an inhibitor of mitochondrial complex II. Since OPA3 is implicated in mitochondrial health, inhibiting complex II would impair mitochondrial function, thereby functionally inhibiting OPA3's activity. | ||||||
Carboxine | 5234-68-4 | sc-234286 | 250 mg | $21.00 | 1 | |
Carboxin inhibits succinate dehydrogenase in the mitochondrial electron transport chain. By impeding this enzyme's activity, it can indirectly inhibit OPA3 by compromising mitochondrial function and integrity. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Sodium azide inhibits cytochrome c oxidase in the mitochondrial electron transport chain. As OPA3 is associated with mitochondrial function, hindering cytochrome c oxidase can lead to mitochondrial dysfunction, thus inhibiting OPA3 activity. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
Carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP) uncouples oxidative phosphorylation, leading to a collapse in mitochondrial membrane potential. This can inhibit OPA3's function indirectly by impairing the mitochondrial environment it is involved in. | ||||||