Olr235 Activators
Chemical activators of Olr235 can initiate a cascade of intracellular events leading to its activation through various signaling pathways. Forskolin, for instance, directly stimulates adenylyl cyclase, thereby increasing the levels of cAMP within the cell. This rise in cAMP activates protein kinase A (PKA), which is capable of phosphorylating Olr235, leading to its activation. Similarly, Phorbol 12-myristate 13-acetate (PMA) and Bryostatin 1 bind and modulate protein kinase C (PKC), prompting the phosphorylation and subsequent activation of Olr235. Thapsigargin and Cyclopiazonic Acid both increase cytosolic calcium by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPases (SERCAs), while Ionomycin directly increases intracellular calcium levels by forming complexes with calcium ions and facilitating their transport across the membrane. This calcium influx can activate calcium-dependent kinases, which phosphorylate Olr235.
Other compounds such as Calyculin A and Okadaic Acid function by inhibiting protein phosphatases like PP1 and PP2A, which normally dephosphorylate proteins. The inhibition of these phosphatases prevents the dephosphorylation of Olr235, resulting in its maintained or enhanced activation state. BAY K8644 and FPL 64176 exert their effects by modulating calcium channels, leading to an increased calcium influx that activates calcium-dependent kinases, which in turn activate Olr235. Lastly, Anisomycin, by activating stress-activated protein kinases, can also facilitate the phosphorylation and activation of Olr235 as part of the cellular response to stress. Each of these chemicals, through their distinct molecular mechanisms, can effectively activate Olr235, engaging it in their respective signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which is involved in the phosphorylation of many protein targets, including Olr235, thereby activating it within its signaling cascade. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can activate calcium-dependent kinases. These kinases are capable of phosphorylating Olr235, resulting in its activation through calcium signaling pathways. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Calyculin A is a protein phosphatase inhibitor that prevents the dephosphorylation of proteins, which can maintain or increase the phosphorylation state of Olr235, leading to its sustained activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to an increase in cytosolic calcium levels. The elevated calcium levels activate calcium-dependent kinases that can phosphorylate and activate Olr235. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
BAY K8644 selectively activates L-type calcium channels, which increases calcium influx and can lead to the activation of Olr235 through calcium-dependent phosphorylation mechanisms. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $240.00 | 9 | |
Bryostatin 1 binds to and modulates protein kinase C (PKC). The activation of PKC leads to the phosphorylation of various proteins, including Olr235, thus promoting its activation within the signaling pathway. | ||||||
FPL-64176 | 120934-96-5 | sc-201491 | 5 mg | $81.00 | 1 | |
FPL 64176 modulates calcium channels to increase intracellular calcium, which activates calcium-dependent kinases that can phosphorylate and activate Olr235. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $173.00 $612.00 | 3 | |
Cyclopiazonic Acid is a SERCA inhibitor that increases cytosolic calcium concentration, similar to Thapsigargin, and can thereby activate Olr235 through calcium-dependent signaling pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin activates stress-activated protein kinases, which may lead to the phosphorylation and activation of Olr235 as part of the cellular stress response pathway. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is an inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels of proteins, which includes the activation of Olr235. | ||||||