Olr203 Activators
Chemical activators of Olr203 can engage in various cellular mechanisms to ensure its activation. Calcium ionophore A23187 and ionomycin function as ionophores that facilitate the increase of intracellular calcium levels, which is a common intracellular signal that can lead to the activation of Olr203. The elevation of intracellular calcium can result from the activity of BAY K8644 as well, which selectively opens L-type calcium channels. Once inside the cell, calcium ions can bind to Olr203 or activate calcium-dependent kinases that can phosphorylate and activate Olr203, suggesting a direct influence on the protein's activity. Similarly, thapsigargin serves to increase cytosolic calcium by inhibiting the calcium pumps of the sarcoplasmic and endoplasmic reticulum, thwarting their ability to sequester calcium, thereby leading to the activation of calcium-sensitive pathways that include Olr203.
Additionally, forskolin raises cyclic AMP (cAMP) levels, which activates protein kinase A (PKA), and PKA can target Olr203 for phosphorylation, leading to its activation. Phorbol 12-myristate 13-acetate (PMA) and Diacylglycerol (DiC8) operate through protein kinase C (PKC), with PMA being a direct activator and DiC8 acting as a diacylglycerol analog to stimulate PKC which, in turn, can phosphorylate and activate Olr203. Anisomycin, by activating stress-activated protein kinases, can also lead to the phosphorylation and subsequent activation of Olr203. Inhibition of dephosphorylation can maintain Olr203 in an active state, and chemicals such as Okadaic Acid and Calyculin A inhibit protein phosphatases 1 and 2A, which would otherwise dephosphorylate and deactivate Olr203. Chelerythrine Chloride, although a PKC inhibitor, can induce changes that lead to Olr203 activation, possibly through compensatory mechanisms within the cell signaling network. Furthermore, Bryostatin 1 modulates PKC, which can lead to the phosphorylation and hence activation of Olr203, highlighting the diverse array of chemical interactions that can regulate the activity state of Olr203.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
This chemical increases intracellular calcium levels which can activate Olr203 by inducing conformational changes or activating calcium-dependent kinases that phosphorylate and activate Olr203. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as a calcium ionophore facilitating the influx of calcium ions, leading to the activation of Olr203 through changes in calcium concentrations that can activate related intracellular signaling pathways. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
BAY K8644 is an L-type calcium channel agonist that causes these channels to open, allowing calcium ions to enter the cell and activate Olr203 by altering intracellular calcium levels. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to a rise in cytosolic calcium levels which can activate Olr203 as the protein is sensitive to changes in calcium ion concentrations. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which can then phosphorylate and activate Olr203. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $46.00 $249.00 | 2 | |
DiC8 acts as a synthetic analog of diacylglycerol, a direct activator of PKC, which in turn can phosphorylate and activate Olr203. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin activates stress-activated protein kinases, which can phosphorylate Olr203, leading to its activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid inhibits protein phosphatases 1 and 2A, preventing dephosphorylation of proteins, which would keep Olr203 in a phosphorylated and active state. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A, like Okadaic Acid, is a potent inhibitor of protein phosphatases 1 and 2A, and by inhibiting the dephosphorylation process, it can keep Olr203 in an activated state. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
Chelerythrine Chloride, a PKC inhibitor, can lead to changes in phosphorylation states within the cell that can inadvertently result in the activation of Olr203. | ||||||