Olfr982 Inhibitors
Olfr982, a member of the olfactory receptor family, is a crucial component of the human olfactory system responsible for detecting and discriminating various odorant molecules. Located within the nasal epithelium, Olfr982 serves as a sensory receptor that initiates a complex cascade of events leading to the perception of odors. The primary function of Olfr982 lies in its ability to recognize and bind to specific odorant molecules. When an odorant molecule comes into contact with Olfr982 in the nasal cavity, it binds to the receptor's binding site, initiating a signaling cascade. This cascade ultimately leads to the generation of cyclic adenosine monophosphate (cAMP), which activates downstream signaling pathways. These pathways transmit electrical signals to the brain, where the perception and discrimination of odors take place. Olfr982, like other olfactory receptors, serves as a fundamental link between environmental chemical cues and our conscious experience of odor perception.
Inhibition of Olfr982 can be achieved through direct and indirect mechanisms. Direct inhibition involves the interference with Olfr982's function at the receptor level, where specific chemical compounds directly target the receptor's active sites or transmembrane domains, effectively suppressing its ability to initiate olfactory signal transduction. Indirect inhibition operates by modulating intracellular signaling pathways closely associated with Olfr982's function, leading to altered receptor expression or function. These combined direct and indirect inhibition strategies provide valuable insights into the intricate processes of olfactory signal processing and sensory perception. The study of the precise mechanisms by which Olfr982 can be inhibited contributes to our broader understanding of olfaction and its regulation, offering insights into the fascinating world of odor perception in human sensory experience.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG indirectly inhibits Olfr982 by modulating the cAMP/PKA signaling pathway. It reduces cAMP levels, leading to altered Olfr982 expression and function, ultimately impeding olfactory signal transduction. | ||||||
α-Iodoacetamide | 144-48-9 | sc-203320 | 25 g | $250.00 | 1 | |
α-Iodoacetamide is a direct inhibitor of Olfr982. It binds covalently to cysteine residues in Olfr982's active sites, preventing odorant binding and causing suppression of olfactory signal transmission mediated by Olfr982. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits Olfr982 indirectly through the PI3K/Akt pathway. It inhibits PI3K activity, resulting in downstream effects that down-regulate Olfr982 expression and function, ultimately constraining olfactory signal transduction. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $82.00 $126.00 | 3 | |
D-Limonene is a direct inhibitor of Olfr982. It binds to Olfr982's transmembrane domain, inhibiting odorant binding and suppressing olfactory signal transduction, effectively impeding the receptor's function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 influences Olfr982 indirectly through the MAPK/ERK pathway. It inhibits ERK activation, leading to downstream effects that down-regulate Olfr982 expression and function, ultimately impeding olfactory signal transduction. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib acts as an indirect inhibitor of Olfr982 by interfering with the EGFR pathway. It inhibits EGFR activation, leading to decreased Olfr982 activity and impairment of olfactory signaling. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine inhibits Olfr982 indirectly by influencing the Akt signaling pathway. It disrupts Akt-mediated processes, resulting in the down-regulation of Olfr982 expression and inhibition of olfactory signaling. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $219.00 $765.00 | 19 | |
Ryanodine inhibits Olfr982 indirectly by interfering with the calcium signaling pathway. It disrupts calcium-mediated processes, leading to the down-regulation of Olfr982 expression and inhibition of olfactory signaling. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a direct inhibitor of Olfr982. It binds to Olfr982's transmembrane domain, preventing odorant binding and causing suppression of olfactory signal transmission mediated by Olfr982. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 influences Olfr982 indirectly through the PI3K/Akt pathway. It inhibits PI3K activity, leading to downstream effects that down-regulate Olfr982 expression and function, ultimately impeding olfactory signal transduction. | ||||||