Olfr94 Activators
Olfr94 is a gene encoding an olfactory receptor that plays a crucial role in the detection of specific odorants. Activation of Olfr94 is essential for initiating the olfactory signaling cascade, which ultimately leads to the perception of odor molecules by the brain. This protein is localized on the surface of olfactory sensory neurons and is responsible for recognizing and transducing odor signals. The activation of Olfr94 primarily involves signaling pathways mediated by cyclic AMP (cAMP). Chemicals such as retinoic acid, forskolin, and dibutyryl-cAMP directly increase cAMP levels, leading to the functional activation of Olfr94. Additionally, compounds like 8-Bromo-cGMP, ionomycin, and phorbol 12-myristate 13-acetate (PMA) modulate intracellular signaling pathways to activate Olfr94.
These chemicals either directly or indirectly influence the cAMP-dependent pathway, resulting in enhanced Olfr94 activity and enabling the recognition of specific odorants. This activation mechanism ensures that Olfr94 fulfills its crucial role in olfaction by contributing to the detection and discrimination of various odor molecules. In summary, Olfr94 is a vital component of the olfactory system, and its activation is essential for odor perception. The listed chemicals, through their specific mechanisms of action, activate Olfr94, thereby facilitating the detection of odorants and contributing to the overall olfactory experience.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid activates Olfr94 by binding to the retinoic acid receptor, which in turn enhances Olfr94 gene expression, leading to increased protein levels and functional activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable analog of cyclic AMP. It directly activates Olfr94 by mimicking the intracellular cAMP signal, resulting in the functional activation of the protein. | ||||||
8-Bromo-cGMP | 51116-01-9 | sc-200316 sc-200316A | 10 mg 50 mg | $104.00 $354.00 | 7 | |
8-Bromo-cGMP activates Olfr94 by modulating the cGMP-dependent signaling pathway, leading to enhanced protein activity and functional activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin activates Olfr94 by inducing calcium influx into cells, which triggers downstream signaling events that culminate in the functional activation of the protein. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Olfr94 by directly stimulating protein kinase C (PKC), leading to phosphorylation events that result in the functional activation of the protein. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol activates Olfr94 through the β-adrenergic receptor pathway, increasing cyclic AMP levels and ultimately leading to functional activation of the protein. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate activates Olfr94 by promoting histone acetylation, which facilitates gene expression and leads to increased protein levels and functional activation. | ||||||
8-CPT-cAMP | 93882-12-3 | sc-201569 sc-201569A | 20 mg 100 mg | $87.00 $316.00 | 19 | |
8-CPT-cAMP is a selective activator of the cAMP-dependent pathway. It activates Olfr94 by elevating intracellular cyclic AMP levels, resulting in functional protein activation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram activates Olfr94 indirectly by inhibiting phosphodiesterase 4 (PDE4), leading to increased cyclic AMP levels and subsequent functional activation of the protein. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Br-cAMP is a cell-permeable analog of cyclic AMP. It activates Olfr94 through the cAMP-dependent pathway, mimicking the intracellular cAMP signal for functional activation. | ||||||