Olfr920 Inhibitors
Chemical inhibitors of Olfr920 utilize various mechanisms to impede its function by targeting different aspects of its signaling and regulatory pathways. Brefeldin A disrupts the function of Olfr920 by inhibiting the ADP-ribosylation factor, which is crucial for the vesicle trafficking between the Golgi apparatus and the endoplasmic reticulum. This inhibition prevents Olfr920 from being properly transported to the cell surface where it can normally interact with its ligands. Genistein, on the other hand, acts by inhibiting tyrosine kinases that are responsible for the phosphorylation of proteins involved in Olfr920's signaling cascade. This results in a reduced capacity for signal transduction, thereby impairing the protein's function. Similarly, Gö 6976 and KT 5720 inhibit protein kinase C and protein kinase A, respectively. Both of these kinases are known to phosphorylate target proteins that participate in Olfr920 signaling pathways, and their inhibition by these specific chemicals results in the suppression of Olfr920 activity.
In addition, Ly294002 and Wortmannin both exert their inhibitory effects on Olfr920 by targeting phosphoinositide 3-kinases, which play a significant role in protein trafficking and signal transduction. The inhibition of these kinases leads to the improper trafficking and localization of Olfr920, thereby impairing its function. PD 98059 and SB 203580 block the mitogen-activated protein kinase kinase and p38 MAP kinase pathways, respectively, which are important for the activation of various cellular responses that Olfr920 is involved in. By preventing the activation of these kinases, these inhibitors directly diminish the signaling capabilities of Olfr920. PP2 and Y-27632 target Src family tyrosine kinases and Rho-associated kinases, respectively, both of which are implicated in signaling pathways and cellular processes that are essential for the functional activity of Olfr920. U73122 disrupts Olfr920 signaling by inhibiting phospholipase C, a critical enzyme in the generation of secondary messengers for G protein-coupled receptor signaling, to which Olfr920 belongs. Lastly, SP600125 inhibits c-Jun N-terminal kinases that are involved in the regulation of gene expression, which can affect the signaling pathways of Olfr920, leading to its functional inhibition.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A inhibits ADP-ribosylation factor (ARF), a small GTPase involved in vesicle trafficking between the Golgi and the endoplasmic reticulum. The proper function of Olfr920 requires correct protein trafficking to the cell surface; thus, the inhibition of ARF by Brefeldin A leads to a blockade of Olfr920 transport and subsequent functional inhibition. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can inhibit receptor-level tyrosine kinases, which could be involved in the phosphorylation state of proteins that interact with or are part of the signaling cascade of Olfr920. By inhibiting these kinases, Genistein can suppress the activation of downstream signaling required for Olfr920 function. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $223.00 | 8 | |
Gö 6976 is a selective inhibitor of protein kinase C (PKC), which is implicated in signal transduction pathways. PKC may phosphorylate proteins that interact with Olfr920, and its inhibition can prevent the activation of Olfr920 signaling pathways, leading to functional inhibition. | ||||||
KT 5720 | 108068-98-0 | sc-3538 sc-3538A sc-3538B | 50 µg 100 µg 500 µg | $97.00 $144.00 $648.00 | 47 | |
KT 5720 is a selective inhibitor of protein kinase A (PKA). PKA can phosphorylate target proteins that are involved in the signaling pathways of Olfr920. By inhibiting PKA, KT 5720 can suppress the phosphorylation events necessary for Olfr920 mediated signal transduction. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Ly294002 is a phosphoinositide 3-kinases (PI3K) inhibitor. PI3K is part of a signaling pathway that can regulate protein trafficking and signal transduction. Inhibition of PI3K by Ly294002 can lead to the functional inhibition of Olfr920 by preventing its proper trafficking and membrane localization. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an inhibitor of mitogen-activated protein kinase kinase (MEK), which is upstream of the extracellular signal-regulated kinase (ERK) pathway. ERK can modulate cellular responses that are crucial for the signaling of Olfr920. By inhibiting MEK, PD 98059 can prevent the activation of ERK and thus inhibit Olfr920 signaling. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. These kinases could be involved in the activation of signaling pathways utilized by Olfr920. The inhibition of Src kinases by PP2 would lead to the suppression of these pathways and inhibition of Olfr920 function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 is a specific inhibitor of p38 MAP kinase. The p38 MAP kinase pathway is implicated in inflammatory responses and could influence the signaling of Olfr920. Inhibition of p38 MAP kinase by SB 203580 leads to the inhibition of downstream signaling events required for Olfr920 function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinases (JNK), which are involved in the regulation of gene expression. JNK may affect the signaling pathways that Olfr920 is part of, and its inhibition by SP600125 can lead to the functional inhibition of Olfr920. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K. Similar to Ly294002, by inhibiting PI3K, Wortmannin can impair the cellular processes essential for the trafficking and function of Olfr920, leading to its functional inhibition. | ||||||