Olfr76 Inhibitors
Olfr76, an olfactory receptor gene found in Mus musculus (house mouse), plays a pivotal role in initiating the neuronal response responsible for the perception of odors. As a member of the G-protein-coupled receptor (GPCR) family, Olfr76 shares a 7-transmembrane domain structure with neurotransmitter and hormone receptors. Its function revolves around recognizing odorant molecules and mediating the transduction of odorant signals through G protein-mediated pathways. This gene is part of the extensive olfactory receptor gene family, characterized by its unique nomenclature within the mouse genome.
Inhibition of Olfr76 can be achieved through various mechanisms, including the targeting of signaling pathways critical to its function. These inhibitors impact calcium channels, cAMP signaling, p38 MAPK pathway, ATP-gated P2X3 receptors, and intracellular calcium signaling. Additionally, some inhibitors affect protein kinase A (PKA) and modulate inositol trisphosphate receptors (IP3Rs), disrupting Olfr76's downstream activation. By interfering with these pathways or processes, Olfr76's function is compromised, leading to reduced sensitivity to odorant molecules and ultimately inhibiting its role in smell perception. Understanding the inhibition of Olfr76 provides valuable insights into the intricate processes governing olfaction in mice. These inhibitors offer potential avenues for research to unravel the complexities of odorant signal transduction. Further studies in this area can enhance our comprehension of olfactory receptor function and its regulation, contributing to a deeper understanding of sensory perception in mice.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF-96365 inhibits Olfr76 by blocking calcium channels, disrupting intracellular calcium signaling. This reduction in intracellular calcium levels leads to decreased sensitivity of Olfr76 to odorant molecules, ultimately inhibiting its function. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $93.00 $356.00 | 13 | |
SQ22536 indirectly inhibits Olfr76 by targeting the cAMP signaling pathway. It inhibits adenylate cyclase, reducing cAMP levels and disrupting the downstream activation of Olfr76, ultimately inhibiting the gene. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 inhibits p38 MAPK, a component of the MAPK pathway downstream of Olfr76. This disruption hinders the activation of transcription factors essential for Olfr76 expression, indirectly inhibiting the gene. | ||||||
NNC 55-0396 | 357400-13-6 | sc-203647A sc-203647 | 5 mg 10 mg | $245.00 $413.00 | 2 | |
NNC 55-0396 inhibits Olfr76 by targeting the ATP-gated P2X3 receptor, a crucial component in olfactory signal transduction. This blockade reduces downstream activation of Olfr76, inhibiting its function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 inhibits the MAPK pathway downstream of Olfr76. This disruption hinders the activation of transcription factors necessary for Olfr76 expression, indirectly inhibiting the gene. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM inhibits Olfr76 by blocking intracellular calcium signaling. It is a cell-permeable calcium chelator that reduces calcium mobilization, leading to decreased sensitivity of Olfr76 to odorant molecules and inhibiting its function. | ||||||
SC514 | 354812-17-2 | sc-205504 sc-205504A | 5 mg 10 mg | $66.00 $89.00 | 13 | |
SC-514 inhibits p38 MAPK, a component of the MAPK pathway downstream of Olfr76. This disruption hinders the activation of transcription factors essential for Olfr76 expression, indirectly inhibiting the gene. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits the MAPK pathway downstream of Olfr76. This disruption hinders the activation of transcription factors necessary for Olfr76 expression, indirectly inhibiting the gene. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB inhibits Olfr76 by targeting intracellular calcium signaling. It modulates inositol trisphosphate receptors (IP3Rs), reducing calcium release and leading to decreased sensitivity of Olfr76 to odorant molecules, ultimately inhibiting its function. | ||||||