Olfr76 Activators
Olfr76, a prominent member of the olfactory receptor family, plays a pivotal role in the sensory perception of odorants within the olfactory system. This receptor is predominantly expressed in the olfactory sensory neurons located in the nasal epithelium, where it is responsible for detecting specific odorant molecules present in the surrounding environment. The primary function of Olfr76 is to initiate a cascade of intracellular events upon activation, leading to the generation of neural signals that are subsequently relayed to the brain for odor recognition and discrimination. Activation of Olfr76 occurs through a highly specific and well-orchestrated process. When volatile odorant molecules are inhaled and enter the nasal cavity, they bind to Olfr76 receptors on the surface of olfactory sensory neurons. This binding event triggers a series of molecular events within the neuron. Initially, odorant binding induces a conformational change in the receptor, leading to its activation. This, in turn, activates a class of specialized proteins known as G-proteins, which are associated with the intracellular domain of Olfr76.
Upon activation, G-proteins initiate a cascade of intracellular signaling events, with cyclic adenosine monophosphate (cAMP) serving as a key second messenger. The increase in cAMP levels subsequently leads to the opening of ion channels, allowing an influx of sodium and calcium ions into the neuron. This influx of ions results in membrane depolarization, which ultimately triggers the generation of action potentials. These action potentials travel along the axons of olfactory sensory neurons, conveying the signal to the olfactory bulb in the brain, where further processing and interpretation of the odorant information occur. In summary, Olfr76 is a critical component of the olfactory system, responsible for the detection and transduction of specific odorant molecules. Its activation involves the binding of odorants, followed by a series of intracellular events that ultimately lead to the generation of neural signals. This receptor's function is essential for our ability to perceive and discriminate various odors in our environment, contributing to our sense of smell.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl Acetate, HPLC | 141-78-6 | sc-360247 sc-360247A | 1 L 4 L | $120.00 $320.00 | ||
Ethyl acetate, a compound with a sweet and fruity aroma, can activate Olfr76 by directly binding to it. This ester induces a conformational change in the receptor, activating the associated G-protein, leading to signaling pathways responsible for the perception of fruity scents. | ||||||
Benzyl alcohol | 100-51-6 | sc-326216B sc-326216 sc-326216A | 250 ml 1 L 5 L | $31.00 $102.00 $408.00 | ||
Benzyl alcohol, with its mild, floral aroma, can activate Olfr76. It interacts with the receptor, triggering a conformational change and activating downstream G-protein mediated signaling pathways, essential in olfactory perception processes. | ||||||
3-Methyl-1-butanol | 123-51-3 | sc-231818 sc-231818A | 500 ml 1 L | $70.00 $93.00 | ||
3-Methyl-1-butanol, with a banana-like odor, can activate Olfr76 through direct binding. As an alcohol, it interacts with olfactory receptors by binding to them, leading to the activation of the G-protein coupled receptor pathway, a key mechanism in the detection of banana-like odors. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $46.00 $69.00 | ||
Methyl salicylate, known for its wintergreen odor, can activate Olfr76 by direct interaction. Upon binding, it triggers a conformational change in the receptor, leading to G-protein mediated signaling pathways for the perception of minty scents. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $46.00 $71.00 $108.00 | ||
Linalool, present in lavender and other aromatic plants, can activate Olfr76 by binding to the receptor. This interaction induces a conformational change, leading to G-protein activation and signaling pathways crucial for the detection of floral and spicy odors. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $31.00 $153.00 | ||
Citronellol, a constituent of rose and geranium oils, can activate Olfr76 through direct binding. Its interaction with the receptor activates the G-protein, initiating signaling pathways necessary for the perception of floral scents. | ||||||
Geranyl acetate | 105-87-3 | sc-235243 | 25 g | $40.00 | ||
Geranyl acetate, known for its floral and fruity aroma, can activate Olfr76 by binding to the receptor. This interaction induces a conformational change, leading to the activation of G-protein signaling pathways crucial for the detection of floral and fruity odors. | ||||||
cis-3,7-Dimethyl-2,6-octadien-1-ol | 106-25-2 | sc-234382 | 5 ml | $51.00 | ||
cis-3,7-Dimethyl-2,6-octadien-1-ol, with a sweet rose-like aroma, can activate Olfr76 by directly interacting with the receptor. This binding induces a conformational change, leading to G-protein activation and signaling pathways important for the perception of rose-like odors. | ||||||