NNC 55-0396 (CAS 357400-13-6)
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NNC 55-0396 is a chemical that functions as a selective and potent inhibitor of phosphodiesterase 7 (PDE7). Its mechanism of action involves targeting and inhibiting the activity of PDE7, which plays a role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP). By inhibiting PDE7, NNC 55-0396 effectively increases the levels of cAMP within cells, leading to downstream effects on various cellular processes and signaling pathways. Nnc 55-0396′s function in experimental applications involves modulating intracellular signaling cascades and gene expression, ultimately influencing cellular responses and physiological functions. Its mechanism of action at the molecular level involves disrupting the hydrolysis of cAMP, thereby prolonging its intracellular effects and impacting cellular homeostasis. NNC 55-0396 is valuable for investigating the role of PDE7 and cAMP signaling in cellular physiology and pathophysiology within development applications.
NNC 55-0396 (CAS 357400-13-6) References
- NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels. | Huang, L., et al. 2004. J Pharmacol Exp Ther. 309: 193-9. PMID: 14718587
- Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396. | Li, M., et al. 2005. Cardiovasc Drug Rev. 23: 173-96. PMID: 16007233
- Is there a role for T-type Ca2+ channels in regulation of vasomotor tone in mesenteric arterioles? | Jensen, LJ. and Holstein-Rathlou, NH. 2009. Can J Physiol Pharmacol. 87: 8-20. PMID: 19142211
- Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor. | Quesada, A., et al. 2011. Eur J Pharmacol. 659: 30-6. PMID: 21256842
- Ca2+ channel inhibitor NNC 55-0396 inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells. | Son, YK., et al. 2014. J Pharmacol Sci. 125: 312-9. PMID: 24989838
- NNC 55-0396, a T-type Ca2+ channel inhibitor, inhibits angiogenesis via suppression of hypoxia-inducible factor-1α signal transduction. | Kim, KH., et al. 2015. J Mol Med (Berl). 93: 499-509. PMID: 25471482
- Blockade by NNC 55-0396, mibefradil, and nickel of calcium and exocytotic signals in chromaffin cells: implications for the regulation of hypoxia-induced secretion at early life. | Fernández-Morales, JC., et al. 2015. Eur J Pharmacol. 751: 1-12. PMID: 25622555
- T-type calcium channel antagonists, mibefradil and NNC-55-0396 inhibit cell proliferation and induce cell apoptosis in leukemia cell lines. | Huang, W., et al. 2015. J Exp Clin Cancer Res. 34: 54. PMID: 25989794
- Effect of CatSper and Hv1 Channel Inhibition on Progesterone Stimulated Human Sperm. | Keshtgar, S., et al. 2018. J Reprod Infertil. 19: 133-139. PMID: 30167393
- Progesterone induces the release of bull spermatozoa from oviductal epithelial cells. | Romero-Aguirregomezcorta, J., et al. 2019. Reprod Fertil Dev. 31: 1463-1472. PMID: 31030724
- NNC 55-0396, a T-type calcium channel blocker, protects against the brain injury induced by middle cerebral artery occlusion and reperfusion in mice. | Matsuda, S., et al. 2019. J Pharmacol Sci. 140: 193-196. PMID: 31235271
- T-Type Calcium Channel Inhibitors Induce Apoptosis in Medulloblastoma Cells Associated with Altered Metabolic Activity. | Sedeeq, M., et al. 2022. Mol Neurobiol. 59: 2932-2945. PMID: 35243582
- Tetralol derivative NNC-55-0396 induces glioblastoma cell death by activating IRE1α, JNK1 and calcium signaling. | Visa, A., et al. 2022. Biomed Pharmacother. 149: 112881. PMID: 35367758
- CatSper and its CaM-like Ca2+ sensor EFCAB9 are necessary for the path chirality of sperm. | Wiesehöfer, C., et al. 2022. FASEB J. 36: e22288. PMID: 35438819
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NNC 55-0396, 5 mg | sc-203647A | 5 mg | $245.00 | |||
NNC 55-0396, 10 mg | sc-203647 | 10 mg | $413.00 |