Olfr726 Inhibitors
Olfr726, a member of the olfactory receptor family 4, plays a pivotal role in the sensory perception of smells in Mus musculus (house mouse). As a typical olfactory receptor, Olfr726 belongs to the vast family of G-protein-coupled receptors (GPCRs), characterized by a 7-transmembrane domain structure. This structural feature allows Olfr726 to interact with odorant molecules in the nasal cavity, initiating a series of events that result in the perception of various scents.
The primary function of Olfr726 is to recognize and transduce signals from odorant molecules, which is crucial for the perception of smells. Inhibition of Olfr726 can be achieved through direct and indirect means. Direct inhibitors, such as Cimetidine, specifically target the receptor, preventing odorant binding and consequently disrupting the initiation of neuronal responses responsible for the perception of smells. Indirect inhibitors, including SKF 96365, Verapamil, and others, influence signaling pathways and cellular processes related to GPCRs. For example, Verapamil acts as a calcium channel blocker, impacting calcium influx and downstream signaling, ultimately leading to impaired olfactory perception. In summary, Olfr726 is a fundamental component of the olfactory system in house mice, enabling the recognition and perception of smells. Inhibition of Olfr726 can be achieved through various chemical compounds, each with its unique mechanism of action. These inhibitors shed light on the intricate processes involved in olfactory perception, contributing to our understanding of sensory physiology in rodents.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
Cimetidine is a direct inhibitor of Olfr726, specifically targeting the receptor and preventing the binding of odorant molecules. This inhibition disrupts the initiation of neuronal responses responsible for the perception of smells. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF 96365 is an indirect inhibitor that disrupts the shared 7-transmembrane domain structure of GPCRs, including Olfr726. It impairs the receptor's structural integrity, leading to compromised odorant recognition and inhibited G protein-mediated signaling. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is an indirect inhibitor that acts as a calcium channel blocker, influencing calcium influx and affecting the downstream signaling cascade of Olfr726. This leads to reduced functionality in perceiving odorants. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
Pertussis Toxin (PTX) is an indirect inhibitor that interferes with the GPCR signaling pathway. PTX modifies G-proteins, disrupting downstream signaling from Olfr726, ultimately impairing the perception of odorants. | ||||||
Scopolamine | 51-34-3 | sc-473216 sc-473216A sc-473216B | 100 mg 500 mg 1 g | $169.00 $496.00 $771.00 | 2 | |
Scopolamine is an indirect inhibitor that targets muscarinic acetylcholine receptors, affecting neurotransmitter signaling and potentially altering neuronal responses to odorants through cross-talk with Olfr726. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $50.00 $128.00 | ||
Lidocaine is an indirect inhibitor that blocks sodium channels, influencing neuronal excitability and potentially modulating Olfr726's responses to odorants. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A is an indirect inhibitor that influences the calcineurin-NFAT signaling pathway. By inhibiting calcineurin, it indirectly affects Olfr726's function, reducing the perception of odors. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-Acetylcysteine is an indirect inhibitor that modulates oxidative stress pathways. It reduces oxidative stress, which can influence the neuronal response to odorants mediated by Olfr726. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an indirect inhibitor that affects calcium signaling in neurons, modulating intracellular calcium levels and indirectly influencing Olfr726's function in transducing odorant signals by altering calcium-dependent processes in olfactory neurons. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol is an indirect inhibitor that acts on adrenergic receptors, potentially influencing the sympathetic nervous system's impact on olfactory perception and Olfr726's responses to odorants. | ||||||