Olfr484 Inhibitors
Olfr484, a G protein-coupled receptor (GPCR), stands as a pivotal component in the intricate machinery of olfactory signal transduction within sensory neurons. Operating as a molecular sensor, Olfr484 plays a central role in detecting and transducing diverse olfactory stimuli, contributing significantly to the complex process of olfaction. When stimulated by specific odorant molecules, Olfr484 triggers a cascade of intracellular signaling events, ultimately culminating in the generation of neuronal responses and the nuanced perception of distinct smells. The specificity of Olfr484's response lies in its ability to recognize and interact with unique ligands, facilitating the translation of olfactory input into discernible sensory information. The inhibition of Olfr484 involves a sophisticated interplay of signaling pathways and cellular processes intricately linked to its regulation. Various inhibitors act on crucial components within these pathways, impacting the finely tuned balance necessary for proper Olfr484 function. These pathways include PI3K/AKT, p38 MAPK, G protein-coupled receptor desensitization, PKC, cAMP, Wnt, Ras/Raf/MEK/ERK, CaMKII, NF-κB, JAK/STAT, GSK-3β, and mTOR. The inhibition mechanisms encompass diverse strategies such as disrupting phosphorylation cascades, altering secondary messenger levels, and interfering with regulatory feedback loops. By modulating these intricate cellular interactions, the inhibitors collectively suppress Olfr484 expression and activity, unveiling the complexities of olfactory signaling regulation at the molecular level.
Understanding the detailed molecular mechanisms underlying Olfr484 and its inhibition not only enhances our comprehension of sensory perception but also sheds light on the intricate interplay between cellular components in olfactory signal transduction. The orchestrated regulation of Olfr484 reflects the finely tuned balance required for the accurate interpretation of olfactory stimuli, showcasing the remarkable complexity of cellular processes in sensory processing. This exploration of Olfr484 and its inhibition contributes valuable insights into the broader landscape of molecular events that govern olfactory signaling, opening avenues for further exploration in the captivating realm of sensory perception.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor targeting the PI3K/AKT pathway. Disrupts Olfr484 indirectly by inhibiting downstream signaling cascades, perturbing the intracellular environment crucial for Olfr484 activation and expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAPK inhibitor disrupting the p38 MAPK pathway involved in Olfr484 regulation. Interferes with the phosphorylation events downstream, leading to altered gene expression patterns and consequent inhibition of Olfr484. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
cAMP phosphodiesterase inhibitor influencing cAMP levels, a secondary messenger in Olfr484 signaling. Maintains elevated cAMP, disrupting the normal feedback mechanisms, leading to decreased Olfr484 expression through altered transcriptional and post-translational processes. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
Wnt signaling pathway inhibitor targeting the Wnt signaling pathway linked to Olfr484 regulation. Modulates intracellular events downstream of Wnt, affecting the intricate crosstalk that indirectly influences Olfr484 expression by disrupting the associated molecular network. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Ras/Raf/MEK/ERK pathway inhibitor disrupting the Ras/Raf/MEK/ERK pathway, intricately involved in Olfr484 signaling. Alters the phosphorylation cascade, leading to downstream changes in gene expression and suppression of Olfr484 by interfering with its regulatory network. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
CaMKII inhibitor impacting the calcium signaling pathway crucial for Olfr484 activation. Alters the downstream effectors and disrupts the finely tuned intracellular calcium levels, indirectly inhibiting Olfr484 expression by interfering with the intricate calcium-dependent regulatory mechanisms. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
NF-κB pathway inhibitor targeting the NF-κB pathway associated with Olfr484 regulation. Modulates the nuclear translocation of NF-κB, influencing the transcriptional landscape and indirectly suppressing Olfr484 expression by disrupting the dynamic regulatory interactions within the pathway. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
JAK/STAT signaling inhibitor affecting the Janus kinase (JAK) and Signal Transducer and Activator of Transcription (STAT) pathway. Alters the phosphorylation events downstream, influencing Olfr484 expression by disrupting the intricate signaling cascades associated with JAK/STAT pathway activation. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $153.00 $520.00 | 4 | |
GSK-3β inhibitor impacting the glycogen synthase kinase-3 beta pathway. Alters the phosphorylation status of key proteins involved in Olfr484 regulation, indirectly influencing gene expression patterns and suppressing Olfr484 through disruption of the associated regulatory mechanisms. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor affecting the mammalian target of rapamycin pathway. Disrupts the downstream signaling cascades, leading to altered cellular processes crucial for Olfr484 expression. It indirectly inhibits Olfr484 by interfering with the intricate molecular events associated with mTOR pathway activation. | ||||||