Olfr470 Inhibitors
Olfr470, a crucial member of the olfactory receptor family, plays a pivotal role in initiating neuronal responses that underlie the perception of various odors. As a G-protein-coupled receptor (GPCR) with a 7-transmembrane domain structure, Olfr470 shares structural characteristics with neurotransmitter and hormone receptors. Its primary function involves the recognition and G protein-mediated transduction of odorant signals within the nasal cavity, contributing significantly to the diversity of olfactory experiences.
Inhibition of Olfr470 involves a sophisticated interplay of various chemical inhibitors targeting specific cellular pathways crucial for olfactory signal transduction. Compounds directly hindering muscarinic receptor activity, disrupting p38 MAPK and PI3K-dependent events, inhibiting vesicle trafficking, modulating CaMKII and PKA activities, and interfering with ryanodine receptors collectively contribute to Olfr470 inhibition. These intricate mechanisms highlight the depth of understanding required to unravel the complexities of olfactory receptor function and underscore the interplay of molecular events crucial for regulating Olfr470's role in olfactory perception. Exploring these mechanisms serves as a foundation for advancing our understanding of olfactory processes, unraveling the molecular intricacies governing the perception of diverse odors mediated by Olfr470 in this organism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pirenzepine Dihydrochloride | 29868-97-1 | sc-204197 | 100 mg | $69.00 | 3 | |
As a muscarinic receptor antagonist, pirenzepine directly inhibits Olfr470 by hindering G protein-mediated signaling cascades associated with olfactory transduction. It specifically targets muscarinic receptors, disrupting their activity and impairing the recognition and transduction of odorant signals by Olfr470 within the olfactory system. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
An inhibitor of p38 mitogen-activated protein kinase (MAPK), SB-203580 indirectly inhibits Olfr470 by disrupting the p38 MAPK pathway. This disruption negatively impacts G protein-mediated transduction of odorant signals, altering the receptor's ability to initiate a neuronal response and perceive odors effectively. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A phosphoinositide 3-kinase (PI3K) inhibitor, wortmannin influences intracellular signaling pathways crucial for Olfr470 function. By disrupting PI3K-dependent events, this chemical indirectly inhibits Olfr470, impairing the normal transduction of odorant signals and negatively impacting G protein-mediated responses of the olfactory receptor. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
An inhibitor of vesicle trafficking, brefeldin A disrupts Golgi apparatus function and indirectly inhibits Olfr470. This disruption affects the proper localization and functioning of olfactory receptors, impairing the recognition and transduction of odorant signals within the nasal cavity. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
A CaMKII inhibitor, KN-93 modulates CaMKII-dependent processes in olfactory signal transduction. This chemical indirectly inhibits Olfr470 by interfering with calcium-calmodulin-dependent kinase II (CaMKII), disrupting downstream events crucial for G protein-mediated transduction of odorant signals. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
A selective MEK inhibitor, U0126 disrupts the MAPK pathway. This compound indirectly inhibits Olfr470 by interfering with MAPK-dependent events, negatively impacting G protein-mediated transduction of odorant signals. The disruption occurs at the level of MEK, influencing downstream events crucial for olfactory perception. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
A ryanodine receptor antagonist, dantrolene indirectly inhibits Olfr470 by disrupting calcium-dependent processes. This disruption affects the intracellular calcium levels crucial for olfactory signal transduction, impairing the recognition and transduction of odorant signals by Olfr470 within the nasal cavity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A selective MEK inhibitor, PD 98059 disrupts the MAPK pathway. This compound indirectly inhibits Olfr470 by interfering with MAPK-dependent events, negatively impacting G protein-mediated transduction of odorant signals. The disruption occurs at the level of MEK, influencing downstream events crucial for olfactory perception. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A phosphoinositide 3-kinase (PI3K) inhibitor, LY294002 influences intracellular signaling pathways crucial for Olfr470 function. By disrupting PI3K-dependent events, this chemical indirectly inhibits Olfr470, impairing the normal transduction of odorant signals and negatively impacting G protein-mediated responses of the olfactory receptor. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
A Src family kinase inhibitor, PP2 modulates Src-dependent processes in olfactory signal transduction. This compound indirectly inhibits Olfr470 by disrupting Src-dependent events, impairing the normal transduction of odorant signals and negatively impacting G protein-mediated responses of the olfactory receptor. | ||||||