Olfr460 Inhibitors
Olfr460, a pivotal member of the olfactory receptor family, orchestrates the initiation of neuronal responses to odorant molecules, leading to the perception of smell. As a G-protein-coupled receptor (GPCR), Olfr460 shares structural features with neurotransmitter and hormone receptors, playing a crucial role in the intricate process of odorant signal transduction. The olfactory receptor gene family, particularly exemplified by Olfr460, constitutes the largest in the genome, underscoring its significance in olfactory perception.
Inhibition of Olfr460 involves a diverse set of chemical interventions targeting various GPCR-associated pathways. Rapamycin suppresses mTOR-dependent events, impacting downstream GPCR signaling pathways and indirectly inhibiting Olfr460. Wortmannin disrupts PI3-kinase-dependent processes involved in GPCR-mediated signal transduction. Thapsigargin influences calcium signaling by inhibiting the SERCA pump, potentially impacting Olfr460 through calcium-dependent processes. Additionally, NF-κB inhibitor modulates NF-κB signaling, affecting GPCR-related pathways, while BAPTA-AM, a calcium chelator, alters calcium-dependent processes. SB203580, a p38 MAP kinase inhibitor, impacts MAPK signaling, and LY294002 inhibits PI3-kinase, both potentially influencing Olfr460 function through their respective pathways. These inhibitors offer valuable insights into potential interventions for Olfr460, providing a nuanced understanding of the intricate mechanisms involved in olfactory signal transduction at the molecular level.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor affecting cellular processes associated with olfactory signal transduction. Indirectly inhibits Olfr460 by suppressing mTOR-dependent events, impacting downstream GPCR signaling pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3-kinase inhibitor altering intracellular signaling pathways. Indirectly influences olfactory receptor function by disrupting PI3-kinase-dependent processes involved in GPCR-mediated signal transduction. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
SERCA pump inhibitor influencing calcium signaling. Disrupts GPCR-related pathways by modulating intracellular calcium levels, potentially impacting Olfr460 function through calcium-dependent processes in olfactory signal transduction. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor disrupting MAPK pathway. Influences GPCR-mediated signal transduction, potentially inhibiting Olfr460 function through the downstream modulation of MAPK signaling. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Modulator of NF-κB signaling impacting GPCR-related pathways. Alters intracellular processes, potentially inhibiting Olfr460 function through the disruption of NF-κB-mediated cascades involved in olfactory signal transduction. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
Intracellular calcium chelator affecting GPCR-mediated signal transduction. Alters calcium-dependent processes, indirectly influencing Olfr460 function by modulating downstream signaling cascades. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAP kinase inhibitor impacting MAPK signaling pathways. Modulates cellular responses downstream of GPCR activation, potentially inhibiting Olfr460 function through the MAPK cascade. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3-kinase inhibitor impacting GPCR-related signaling pathways. Modulates intracellular processes, indirectly influencing Olfr460 function through the disruption of PI3-kinase-dependent cascades. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
PKC inhibitor targeting downstream GPCR signaling. Modifies intracellular pathways involved in olfactory signal transduction, potentially inhibiting Olfr460 function through PKC-mediated processes. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
MEK inhibitor affecting the MAPK pathway. Alters GPCR-related signal transduction, potentially inhibiting Olfr460 function through downstream modulation of the MAPK cascade. | ||||||