Olfr460 Activators
Chemical activators of Olfr460, such as Ethyl acetate, Isoamyl alcohol, and Citronellol, function by directly interacting with the ligand-binding domain of the protein. These chemicals induce conformational changes in Olfr460, essential for activating the G-protein coupled receptor (GPCR) pathway. Binding of these activators to Olfr460 results in the stimulation of adenylate cyclase, subsequently elevating intracellular cyclic AMP (cAMP) levels. This increase in cAMP activates protein kinase A (PKA) and other downstream signaling molecules, leading to various cellular responses.
Chemicals including Geraniol, Nerol, and Methyl anthranilate share a common mechanism in activating Olfr460. They bind to specific sites on the protein, initiating a cascade of intracellular events. This binding alters the protein conformation, effectively triggering the GPCR pathway. The activation of this pathway leads to a series of intracellular reactions, primarily the production of cAMP. This signaling molecule plays a central role in activating downstream effectors, thus propagating the signal initiated by the chemical activators. The downstream effects of these signaling pathways culminate in physiological responses, demonstrating the direct impact these chemical activators have on the functional activity of Olfr460.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl Acetate, HPLC | 141-78-6 | sc-360247 sc-360247A | 1 L 4 L | $120.00 $320.00 | ||
Ethyl acetate activates Olfr460 by directly binding to its ligand-binding domain, causing a conformational change that initiates signal transduction through G-protein coupled receptors, increasing intracellular cAMP levels and leading to cellular responses. | ||||||
3-Methyl-1-butanol | 123-51-3 | sc-231818 sc-231818A | 500 ml 1 L | $70.00 $93.00 | ||
3-Methyl-1-butanol serves as a direct activator of Olfr460 by interacting with its specific odorant binding site. This binding induces allosteric modulation of Olfr460, activating adenylate cyclase through G-protein signaling, thus elevating cAMP levels and initiating downstream effects. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $31.00 $153.00 | ||
Citronellol activates Olfr460 by binding to its odorant recognition site, promoting G-protein coupled receptor pathway activation, increasing cAMP production, and activating protein kinase A, which leads to signal transduction processes. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $44.00 $117.00 | ||
Geraniol selectively activates Olfr460 by interacting with its odorant binding domain. This interaction enhances G-protein coupling, activates adenylate cyclase, resulting in elevated cAMP levels and initiating intracellular signaling events. | ||||||
cis-3,7-Dimethyl-2,6-octadien-1-ol | 106-25-2 | sc-234382 | 5 ml | $51.00 | ||
cis-3,7-Dimethyl-2,6-octadien-1-ol directly activates Olfr460 by binding to its ligand-binding domain, triggering a G-protein activation signaling cascade, stimulating adenylate cyclase, increasing cAMP levels, and activating downstream signaling pathways. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol activates Olfr460 by interacting with its specific odorant binding domain, facilitating the activation of G-protein coupled receptor pathways, increasing cAMP levels, and activating downstream signaling pathways, including protein kinase A. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral directly activates Olfr460 by binding to its ligand recognition site, triggering a conformational change leading to G-protein signaling pathway activation, an increase in intracellular cAMP levels, and subsequent activation of downstream cellular responses. | ||||||
Hexyl acetate | 142-92-7 | sc-215149 sc-215149A | 25 ml 500 ml | $32.00 $57.00 | ||
Hexyl acetate activates Olfr460 by binding to its specific ligand-binding domain, facilitating the activation of G-protein coupled receptor mechanisms, leading to the elevation of cAMP levels, and triggering a cascade of intracellular signaling pathways. | ||||||
Farnesol | 4602-84-0 | sc-204748 sc-204748A | 50 ml 100 ml | $275.00 $367.00 | 2 | |
Farnesol activates Olfr460 through direct interaction with its odorant recognition site, initiating a signaling cascade via G-protein activation, promoting an increase in cAMP levels, and leading to the activation of downstream signaling pathways. | ||||||