Olfr450 Inhibitors
Olfr450, a critical member of the olfactory receptor gene family, plays a pivotal role in the intricate process of odorant signal transduction, leading to the perception of various smells. As a G-protein-coupled receptor (GPCR) with a 7-transmembrane domain structure, Olfr450 is involved in recognizing and mediating the G protein-mediated transduction of odorant signals in the nasal cavity. This receptor's singular coding-exon genes and independent nomenclature underscore its distinctiveness within the genome, contributing to the complexity of the olfactory system.
Inhibition of Olfr450 involves a diverse array of direct and indirect mechanisms. Direct inhibitors, such as Acetophenone and Thiourea, disrupt the binding of odorant molecules to Olfr450, impeding the subsequent G-protein-mediated transduction and diminishing the neuronal responses triggered by its activation. Indirect inhibitors, exemplified by Forskolin and Wortmannin, modulate specific cellular pathways associated with Olfr450 function. Forskolin activates adenylate cyclase, influencing cAMP levels and thereby altering the responsiveness of Olfr450 to odorants. Wortmannin, on the other hand, targets the PI3K-Akt signaling pathway, indirectly influencing Olfr450 and contributing to altered olfactory signal transduction. This intricate interplay between direct and indirect inhibitors unveils the multifaceted nature of Olfr450's regulation and its role in shaping our perception of smells.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acetophenone | 98-86-2 | sc-239189 | 5 g | $20.00 | ||
Direct inhibitor binding to Olfr450, preventing odorant interaction and disrupting G protein-mediated transduction. This interference hampers neuronal responses, diminishing the perception of smells associated with Olfr450 activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Indirect inhibitor activating adenylate cyclase, modulating cAMP levels, and influencing Olfr450 function. This modulation disrupts normal olfactory signal transduction, altering the receptor's responsiveness to specific odorants. | ||||||
Thiourea | 62-56-6 | sc-213038 | 50 g | $37.00 | ||
Direct inhibitor competitively binding to Olfr450, impeding odorant interaction and disrupting normal signal transduction. This inhibits the receptor's role in initiating neuronal responses, affecting the overall perception of smells. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Indirect inhibitor influencing the folate metabolic pathway associated with Olfr450. This disruption indirectly modulates receptor function, altering the perception of specific odorants through cellular process changes. | ||||||
FCM Lysing solution (1x) | sc-3621 | 150 ml | $61.00 | 8 | ||
Direct inhibitor altering ion channels related to olfactory signal transduction, influencing Olfr450 responsiveness to odorants. This disruption decreases neuronal responses, impairing the overall perception of smells associated with Olfr450 activation. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
Indirect inhibitor affecting glucose metabolism pathways linked to Olfr450. Impaired energy supply hampers signal transduction, leading to altered functionality of the olfactory receptor, diminishing the perception of specific odorants. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Direct inhibitor inhibiting protein synthesis processes crucial for Olfr450 functionality. Reduced expression and activity of the receptor result in impaired odorant perception, impacting the overall smell perception associated with Olfr450 activation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Indirect inhibitor targeting the PI3K-Akt signaling pathway linked to Olfr450. Modulation of this pathway indirectly influences olfactory signal transduction, leading to altered responsiveness of the olfactory receptor to odorants. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Direct inhibitor modulating the cAMP signaling pathway associated with Olfr450. Altered cAMP levels influence olfactory receptor function, leading to impaired perception of specific odorants recognized by Olfr450. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Indirect inhibitor affecting intracellular calcium levels linked to Olfr450 signal transduction. Disruption of calcium homeostasis indirectly influences receptor function, altering neuronal responses and diminishing the perception of smells associated with Olfr450 activation. | ||||||