alpha-Bungarotoxin CAS: 11032-79-4
MF: C338H529N97O105S11
MW: 7984.3
An α-neurotoxin which competitively and irreversibly binds and blocks nAChR.

α-Bungarotoxin (CAS 11032-79-4)

α-Bungarotoxin | CAS 11032-79-4 is rated 5.0 out of 5 by 1.
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Application: α-Bungarotoxin is an α-neurotoxin which competitively and irreversibly binds and blocks nAChR
CAS Number: 11032-79-4
Molecular Weight: 7984.3
Molecular Formula: C338H529N97O105S11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

α-BUNGAROTOXIN binds nicotinic acetylcholine receptors and has been used to isolate and study them. It blocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor but does not depress acetylcholine release from motor nerve endings. α-Bungarotoxin (α-BuTx) has been shown to bind mainly to sequences around the two cysteines at positions 192 and 193 of the AChR α-subunit of most species. It blocks nicotine-induced increase of intracellular Ca2+ in PC12 cells, and prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-bungarotoxin on neuronal AChR to be highly specific for the α7-subtype, but not for the α3β4 subtype. α-BUNGAROTOXIN is an inhibitor of AChR α7.


References

1. Ruan, K.H., et al. 1990. Proc. Natl. Acad. Sci. U.S.A. 87: 6156-6160. PMID: 2385590
2. Lin, S.R., et al. 1992. Biochim. Biophys. Acta. 1159: 255-261. PMID: 1390930
3. Sorenson, E.M., et al. 1992. J. Comp. Neurol. 323: 1-12. PMID: 1430311
4. Motomura, M., et al. 1992. Neurosci. Lett. 143: 139-142. PMID: 1436658
5. Zhang, Z.W., et al. 1994. Neuron. 12: 167-177. PMID: 7507338
6. Vincent, A., et al. 1998. Neurochem. Int. 32: 427-433. PMID: 9676741
7. López, M.G., et al. 1998. Proc. Natl. Acad. Sci. U.S.A. 95: 14184-14189. PMID: 9826675

Physical State :
Solid
Derived From :
Venom of the banded or Formosan krait (Bungarus multicinctus, an elapid snake).
Sequence :
H-Ile-Val-Cys3-His-Thr-Thr-Ala-Thr-Ser-Pro-Ile-Ser-Ala-Val-Thr-Cys16-Pro-Pro-Gly-Glu-Asn-Leu-Cys23-Tyr-Arg-Lys-Met-Trp-Cys29-Asp-Ala-Phe-Cys33-Ser-Ser-Arg-Gly-Lys-Val-Val-Glu-Leu-Gly-Cys44-Ala-Ala-Thr-Cys48-Pro-Ser-Lys-Lys-Pro-Tyr-Glu-Glu-Val-Thr-Cys59-Cy
Solubility :
Soluble in water (1), PBS, and any aqueous buffer.
Storage :
Desiccate at -20° C
Density :
1.19 g/cm3 (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
IC50 :
AChR alpha 7 : IC50 = 1.6 nM; nicotine-induced increase of intracellular Ca2+: IC50 = 0.31 µM ( PC12 cells)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
EI6201400
PubChem CID :
44264212
Merck Index :
14: 1488
MDL Number :
MFCD01779815
EC Number :
234-266-6

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Certificate of Analysis

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alpha-Bungarotoxin (CAS 11032-79-4)  Product Citations

See how others have used alpha-Bungarotoxin (CAS 11032-79-4). Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 29215705  2018. J. Cell. Physiol. 233: 4972-4980.

PMID: # 26700614  Javed, H. et al. 2016. Mol. Ther. 24: 746-58.

PMID: # 8846777  Zhu, X. et al. 1995. EMBO J. 14: 5842-5848.

Orr-Urtreger, A et al.

Frazier, C et al.

Citations 1 to 5 of 5 total
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Rated 5 out of 5 by from Zhu Zhu, X. et al. (PubMed 8846777) used -Bungarotoxin, an -neurotoxin which competitively and irreversibly binds to nAChR, conjugated with rhodamine in an immunohistochemical staining, to identify the location of neuromuscular synapses. -SCBT Publication Review
Date published: 2015-02-12
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