Olfr446 Inhibitors
Olfr446, a prominent member of the olfactory receptor family, stands as a crucial component in the intricate process of olfactory perception. As a G-protein-coupled receptor (GPCR) with a characteristic 7-transmembrane domain structure, Olfr446 is integral to the recognition and G protein-mediated transduction of signals from odorant molecules. The olfactory receptor proteins, including Olfr446, emerge from single coding-exon genes and constitute the largest gene family in the genome. These receptors play a fundamental role in initiating neuronal responses upon interaction with odorant molecules in the nose, ultimately leading to the perception of smells.
The function of Olfr446 revolves around its capacity to recognize and transduce signals from odorant molecules, a process essential for the perception of smells. Inhibition of Olfr446 encompasses both direct and indirect mechanisms, offering a multifaceted approach to disrupting its function. Direct inhibitors interfere with specific components crucial for Olfr446 activation, such as microtubule dynamics and G protein function. Indirect inhibitors, on the other hand, impact associated signaling pathways like nitric oxide production, norepinephrine release, calcium dynamics, and glutamatergic signaling. These intricate interferences collectively contribute to impaired olfactory receptor function, limiting Olfr446's ability to mediate the transduction of odorant signals and initiate a proper neuronal response to smells. The broad spectrum of inhibition mechanisms sheds light on the complexity of olfactory signal processing and offers valuable insights into the regulatory mechanisms governing olfactory perception.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Direct inhibitor disrupting microtubule dynamics. Paclitaxel binds to and stabilizes microtubules, impairing olfactory neuron structure. This direct inhibition limits the propagation of signals initiated by Olfr446 activation, impacting the receptor's ability to mediate the transduction of odorant signals and perceive smells. | ||||||
L-NG-Nitroarginine Methyl Ester (L-NAME) | 51298-62-5 | sc-200333 sc-200333A sc-200333B | 1 g 5 g 25 g | $48.00 $107.00 $328.00 | 45 | |
Inhibitor of nitric oxide synthase (NOS). L-NAME disrupts nitric oxide production, indirectly inhibiting Olfr446. The altered nitric oxide levels impact olfactory signaling by affecting neuronal response, thereby impairing the transduction of odorant signals and perception of smells. | ||||||
Guanethidine sulfate | 645-43-2 | sc-211570 | 1 g | $238.00 | 10 | |
Inhibitor of norepinephrine release. This indirect inhibitor impacts adrenergic signaling, affecting downstream processes associated with Olfr446 activation. The altered adrenergic signaling limits the receptor's ability to mediate the transduction of odorant signals and initiate a proper neuronal response to smells. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
Intracellular calcium chelator. BAPTA-AM disrupts calcium-dependent processes involved in olfactory signal transduction by Olfr446. The altered calcium dynamics impair the receptor's ability to initiate a neuronal response to smells, limiting the transduction of odorant signals. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Direct inhibitor interfering with G protein function. Pertussis Toxin blocks Gαi signaling, impairing Olfr446 activation. This direct inhibition prevents the normal transduction of odorant signals, limiting the receptor's ability to initiate a proper neuronal response to smells. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
Inhibitor of store-operated calcium entry (SOCE). SKF 96365 disrupts the calcium influx crucial for olfactory signal transduction by Olfr446. The altered calcium dynamics impair the receptor's ability to initiate a neuronal response to smells, limiting the transduction of odorant signals. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Activator of L-type calcium channels. This indirect inhibitor influences calcium dynamics crucial for olfactory signal transduction by Olfr446. The altered calcium influx impairs the receptor's ability to initiate a neuronal response to smells, limiting the transduction of odorant signals. | ||||||
6-Cyano-7-nitroquinoxaline-2,3-dione | 115066-14-3 | sc-505104 | 10 mg | $208.00 | 2 | |
Inhibitor of AMPA and kainate glutamate receptors. CNQX impacts glutamatergic signaling associated with Olfr446 activation. The altered glutamate signaling limits the receptor's ability to mediate the transduction of odorant signals and initiate a proper neuronal response to smells. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Inhibitor targeting the SERCA pump. Thapsigargin disrupts calcium dynamics crucial for olfactory signal transduction by Olfr446. The altered calcium dynamics impair the receptor's ability to initiate a neuronal response to smells, limiting the transduction of odorant signals. | ||||||
Picrotoxin | 124-87-8 | sc-202765 sc-202765A sc-202765B | 1 g 5 g 25 g | $67.00 $286.00 $1326.00 | 11 | |
Antagonist of GABAA receptors. Picrotoxin disrupts GABAergic signaling associated with Olfr446 activation. The altered GABAergic signaling limits the receptor's ability to mediate the transduction of odorant signals and initiate a proper neuronal response to smells. | ||||||