Olfr370 Inhibitors
Or10k2, a member of the olfactory receptor family in Mus musculus, plays a pivotal role in initiating a neuronal response upon interaction with odorant molecules. As a G-protein-coupled receptor (GPCR) with a 7-transmembrane domain structure, Or10k2 is essential for the recognition and G protein-mediated transduction of odorant signals, contributing to the intricate process of smell perception. The unique nomenclature of olfactory receptor genes and proteins in this organism emphasizes the distinctiveness of their functions within the genome.
The inhibition of Or10k2 involves a strategic approach targeting specific cellular processes crucial for efficient olfactory signal transduction. The identified inhibitors act on diverse pathways, focusing on disrupting calcium-dependent signaling events. Monensin A, Thapsigargin, and 2-APB perturb intracellular calcium dynamics, impacting processes essential for Or10k2 function. Nifedipine and BAPTA-AM modulate calcium influx, affecting the transmission of olfactory signals. Additionally, 4-Aminopyridine, U73122, and MAFP alter neuronal excitability and lipid signaling, indirectly influencing Or10k2. Ruthenium Red, SKF96365, CGP37157, and EGTA target various calcium channels and exchangers, further perturbing calcium-dependent processes crucial for olfactory signal transduction. In summary, the inhibition of Or10k2 involves a nuanced interference with specific cellular pathways, disrupting calcium-dependent signaling events that are integral to the efficient transduction of olfactory signals. The identified inhibitors showcase a diverse array of mechanisms that collectively contribute to modulating the function of Or10k2 in the complex landscape of odor perception in Mus musculus.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin A disrupts ion transport and osmotic balance, leading to cellular stress. This disruption indirectly influences Or10k2 by affecting cellular homeostasis, contributing to altered odorant signal transduction. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits SERCA, causing calcium depletion in the endoplasmic reticulum. This disruption indirectly influences Or10k2 by perturbing calcium-dependent signaling pathways crucial for olfactory signal transduction. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB inhibits IP3 receptors, disrupting intracellular calcium release. This interference indirectly impacts Or10k2 by altering calcium-dependent processes essential for efficient olfactory signal transduction. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine inhibits L-type calcium channels, leading to reduced calcium influx. This disruption indirectly influences Or10k2 by modulating calcium-dependent signaling pathways crucial for olfactory signal transduction. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA/AM is a calcium chelator that sequesters intracellular calcium ions. This interference indirectly affects Or10k2 by disrupting calcium-dependent processes vital for efficient olfactory signal transduction. | ||||||
4-Aminopyridine | 504-24-5 | sc-202421 sc-202421B sc-202421A | 25 g 1 kg 100 g | $38.00 $1155.00 $122.00 | 3 | |
4-Aminopyridine inhibits potassium channels, altering membrane potential. This disruption indirectly influences Or10k2 by modulating neuronal excitability and impacting the transmission of olfactory signals. | ||||||
MAFP | 188404-10-6 | sc-203440 | 5 mg | $219.00 | 4 | |
MAFP inhibits calcium-independent phospholipase A2, disrupting lipid signaling. This disruption indirectly influences Or10k2 by altering intracellular signaling cascades crucial for efficient olfactory signal transduction. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Ruthenium Red inhibits transient receptor potential (TRP) channels. This interference indirectly impacts Or10k2 by modulating calcium influx and disrupting TRP channel-dependent processes in olfactory signal transduction. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SK&F 96365 inhibits store-operated calcium channels, disrupting calcium entry. This interference indirectly influences Or10k2 by modulating store-operated calcium-dependent processes crucial for efficient olfactory signal transduction. | ||||||
CGP 37157 | 75450-34-9 | sc-202097 sc-202097A | 5 mg 25 mg | $115.00 $463.00 | 3 | |
CGP 37157 inhibits the mitochondrial Na+/Ca2+ exchanger, leading to calcium retention. This disruption indirectly influences Or10k2 by modulating mitochondrial calcium-dependent processes crucial for olfactory signal transduction. | ||||||