Olfr370 Inhibitors

Or10k2, a member of the olfactory receptor family in Mus musculus, plays a pivotal role in initiating a neuronal response upon interaction with odorant molecules. As a G-protein-coupled receptor (GPCR) with a 7-transmembrane domain structure, Or10k2 is essential for the recognition and G protein-mediated transduction of odorant signals, contributing to the intricate process of smell perception. The unique nomenclature of olfactory receptor genes and proteins in this organism emphasizes the distinctiveness of their functions within the genome.

The inhibition of Or10k2 involves a strategic approach targeting specific cellular processes crucial for efficient olfactory signal transduction. The identified inhibitors act on diverse pathways, focusing on disrupting calcium-dependent signaling events. Monensin A, Thapsigargin, and 2-APB perturb intracellular calcium dynamics, impacting processes essential for Or10k2 function. Nifedipine and BAPTA-AM modulate calcium influx, affecting the transmission of olfactory signals. Additionally, 4-Aminopyridine, U73122, and MAFP alter neuronal excitability and lipid signaling, indirectly influencing Or10k2. Ruthenium Red, SKF96365, CGP37157, and EGTA target various calcium channels and exchangers, further perturbing calcium-dependent processes crucial for olfactory signal transduction. In summary, the inhibition of Or10k2 involves a nuanced interference with specific cellular pathways, disrupting calcium-dependent signaling events that are integral to the efficient transduction of olfactory signals. The identified inhibitors showcase a diverse array of mechanisms that collectively contribute to modulating the function of Or10k2 in the complex landscape of odor perception in Mus musculus.