Olfr362 Activators
Or1b1, an olfactory receptor in the house mouse (Mus musculus), plays a critical role in the olfactory system, the sensory system responsible for the sense of smell. This receptor is part of the extensive family of G-protein-coupled receptors (GPCRs), which are known for their significant role in various physiological processes, including sensory perception. The Or1b1 receptor, like other olfactory receptors, functions by interacting with odorant molecules in the nasal cavity. This interaction triggers a conformational change in the receptor, leading to the activation of an associated G-protein. The activated G-protein then initiates a signaling cascade, typically involving the production of second messengers like cyclic AMP (cAMP), ultimately resulting in a neuronal response that is perceived as a smell.
The activation mechanism of Or1b1, as with other olfactory receptors, is inherently complex due to the vast diversity of odorant molecules and the subtle nuances in how different receptors respond to these molecules. The sensitivity and specificity of Or1b1 to particular odorants are fundamental to its function. Upon binding an odorant, Or1b1 undergoes a structural change that facilitates the exchange of GDP for GTP on the G-protein, leading to its activation. The activated G-protein then influences various effector enzymes, such as adenylyl cyclase, which converts ATP to cAMP. The increase in cAMP levels within the olfactory neuron leads to the opening of ion channels, causing neuronal depolarization and the generation of an action potential. This action potential travels along the olfactory nerve to the brain, where it is processed as a distinct smell. In the context of the olfactory system, the activation of Or1b1 and its subsequent signaling pathway is a critical step in the translation of chemical signals (odorants) into electrical signals that can be interpreted by the brain. The process is highly regulated and finely tuned to ensure accurate perception and discrimination of a wide range of smells. The modulation of this pathway, whether through direct interaction with the receptor or indirect influence on the associated signaling mechanisms, can significantly affect olfactory perception. The understanding of these mechanisms not only sheds light on the fundamental aspects of olfaction but also opens avenues for exploring how the olfactory system adapts and responds to a constantly changing chemical environment.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, a labdane diterpene from the Indian Coleus plant, directly stimulates adenylyl cyclase, leading to increased levels of cyclic AMP (cAMP). Higher cAMP in olfactory receptor neurons can enhance the sensitivity and responsiveness of GPCRs, including Or1b1, by amplifying the signal transduction cascade initiated by odorant binding. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol, a synthetic catecholamine, acts as a non-selective beta-adrenergic receptor agonist. It increases intracellular cAMP levels via adenylyl cyclase activation. This elevation of cAMP can indirectly enhance GPCR-mediated responses, potentially increasing the activity of olfactory receptors like Or1b1. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
3-Isobutyl-1-methylxanthine (IBMX) is a non-selective inhibitor of phosphodiesterases (PDEs). By inhibiting PDEs, IBMX prevents the breakdown of cAMP, thus indirectly potentiating GPCR signaling including that of olfactory receptors by maintaining elevated intracellular cAMP levels. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine, also known as adrenaline, is a hormone and neurotransmitter. It activates adrenergic receptors leading to increased cAMP production via adenylyl cyclase. Elevated cAMP can enhance GPCR signaling including Or1b1, by promoting a more effective odorant signal transduction. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine a neurotransmitter, acts on dopamine receptors which are GPCRs. Its binding can modulate cAMP levels in neurons, indirectly influencing other GPCRs like Or1b1, by altering the intracellular signaling milieu and potentially enhancing olfactory receptor responses. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine, an organic nitrogenous compound, engages with histamine receptors, another class of GPCRs. This interaction can modulate intracellular cAMP levels, indirectly affecting the signaling of olfactory receptors like Or1b1, potentially modifying their responsiveness to odorants. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine, a purine nucleoside, interacts with adenosine receptors (GPCRs). This binding can result in varied effects on cAMP levels depending on the receptor subtype, potentially modulating the signaling pathways of other GPCRs like Or1b1 in olfactory neurons. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) acts through prostaglandin receptors, a subset of GPCRs. It can regulate cAMP levels in cells, thereby indirectly influencing the signaling of other GPCRs including Or1b1, possibly affecting the olfactory receptor's response to odorants. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine is a known antagonist of adenosine receptors and also inhibits phosphodiesterases. This dual action raises cAMP levels and modulates neuronal signaling, potentially impacting GPCR function including the signaling of olfactory receptors like Or1b1. | ||||||
Serotonin hydrochloride | 153-98-0 | sc-201146 sc-201146A | 100 mg 1 g | $116.00 $183.00 | 15 | |
Serotonin hydrochloride, a neurotransmitter, binds to serotonin receptors, a group of GPCRs. This interaction can influence cAMP levels and overall neuronal signaling, potentially impacting the signaling of other GPCRs like Or1b1 in olfactory neurons. | ||||||