Olfr362 Inhibitors
Or1b1, a member of the olfactory receptor family, holds a pivotal role in the intricate process of olfaction, where odorant molecules interact with receptors in the nose, initiating a neuronal response that culminates in the perception of smell. This particular olfactory receptor, Or1b1, is intricately linked to G-protein-coupled receptors (GPCRs) and shares a structural foundation with neurotransmitter and hormone receptors, featuring a 7-transmembrane domain architecture. As a representative of the vast olfactory receptor gene family, Or1b1 is notable for its single coding-exon origin, contributing to the unique nomenclature assigned independently for this organism. The primary function of Or1b1 lies in recognizing and transducing odorant signals through G protein-mediated pathways. The interaction between odorant molecules and olfactory receptor proteins initiates a complex cascade of events leading to the perception of distinct smells. Notably, Or1b1's involvement in this process is underscored by its contribution to the largest gene family in the genome dedicated to olfactory reception. The receptor's specificity in recognizing odorant molecules and its subsequent involvement in GPCR-mediated transduction highlight its significance in shaping the sense of smell.
The inhibition of Or1b1 involves a nuanced interplay of direct and indirect mechanisms. Direct inhibitors act by directly interfering with the olfactory receptor proteins, disrupting their interaction with odorant molecules. This interference hampers the normal G protein-mediated transduction of odorant signals, leading to the inhibition of Or1b1 and consequently hindering the perception of smell. On the other hand, indirect inhibitors modulate specific signaling pathways associated with Or1b1 function. These pathways, such as cyclic nucleotide, MAPK, calcium, cAMP, PI3K/Akt, and NF-κB, serve as intricate networks influencing the expression and function of Or1b1. The alterations induced by these compounds in the downstream components of these signaling cascades result in the indirect inhibition of Or1b1, providing alternative avenues for the regulation of olfactory receptor activity. In summary, the dual approaches of direct interference with receptor-ligand interactions and indirect modulation of crucial signaling pathways showcase potential strategies for the targeted inhibition of Or1b1, shedding light on the complex regulatory mechanisms underlying olfactory reception.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzoic acid | 65-85-0 | sc-203317 sc-203317A sc-203317B | 25 g 100 g 500 g | $20.00 $50.00 $60.00 | ||
Benzoic Acid acts as an indirect inhibitor by influencing the cyclic nucleotide signaling pathway. It disrupts the GPCR-mediated transduction of odorant signals by modulating downstream cyclic nucleotide levels, leading to the indirect inhibition of Or1b1 through altered intracellular signaling cascades. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $102.00 $224.00 | ||
Cinnamic Aldehyde acts as a direct inhibitor by binding to Or1b1 and disrupting the normal activation of G protein-mediated transduction. This direct interference with the olfactory receptor proteins inhibits the recognition and transduction of odorant signals, leading to a suppressed neuronal response. | ||||||
Farnesol | 4602-84-0 | sc-204748 sc-204748A | 50 ml 100 ml | $275.00 $367.00 | 2 | |
Farnesol acts as an indirect inhibitor by modulating the MAPK signaling pathway. It influences the downstream signaling cascades, indirectly inhibiting Or1b1 expression and function. This compound's impact on the cellular processes connected to the MAPK pathway results in the inhibition of the targeted olfactory receptor. | ||||||
(−)-Menthol | 2216-51-5 | sc-202705 sc-202705A | 1 g 50 g | $20.00 $40.00 | 2 | |
Menthol serves as a direct inhibitor of Or1b1 by binding to the olfactory receptor proteins and interfering with their interaction with odorant molecules. This direct disruption of the neuronal response inhibits the perception of smell mediated by Or1b1, hindering the initiation of the olfactory signaling cascade. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isopentyl acetate serves as a direct inhibitor by binding to Or1b1 and impeding the interaction with odorant molecules. This direct interference disrupts the normal G protein-mediated transduction of odorant signals, directly inhibiting the perception of smell mediated by Or1b1. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol acts as an indirect inhibitor by influencing the cAMP signaling pathway. It modulates the downstream components of the cAMP pathway, indirectly inhibiting Or1b1 expression and function. The altered cAMP signaling cascades disrupt the normal transduction of odorant signals, leading to indirect inhibition. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral serves as a direct inhibitor of Or1b1 by binding to the olfactory receptor proteins and interfering with their interaction with odorant molecules. This direct disruption of the neuronal response inhibits the perception of smell mediated by Or1b1, hindering the initiation of the olfactory signaling cascade. | ||||||
Thymol | 89-83-8 | sc-215984 sc-215984A | 100 g 500 g | $97.00 $193.00 | 3 | |
Thymol acts as an indirect inhibitor by influencing the PI3K/Akt signaling pathway. It modulates the downstream components of this pathway, indirectly inhibiting Or1b1 expression and function. The altered PI3K/Akt signaling cascades disrupt the normal transduction of odorant signals, leading to indirect inhibition. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $68.00 | ||
2-Phenylethanol serves as a direct inhibitor of Or1b1 by binding to the olfactory receptor proteins and interfering with their interaction with odorant molecules. This direct disruption of the neuronal response inhibits the perception of smell mediated by Or1b1, hindering the initiation of the olfactory signaling cascade. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $82.00 $126.00 | 3 | |
D-Limonene acts as an indirect inhibitor by influencing the NF-κB signaling pathway. It modulates the downstream components of the NF-κB pathway, indirectly inhibiting Or1b1 expression and function. The altered NF-κB signaling cascades disrupt the normal transduction of odorant signals, leading to indirect inhibition. | ||||||