OCTL2 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin competitively inhibits the transport function of OCTL2 by binding to its substrate recognition sites. This results in a diminished uptake of carnitine, a substrate of OCTL2, thereby inhibiting its transport function across the cell membrane. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil acts as a calcium channel blocker and indirectly diminishes OCTL2 activity by modulating intracellular calcium levels. Elevated intracellular calcium is known to increase the transport function of OCTL2; hence, Verapamil's action leads to reduced OCTL2-mediated transport. | ||||||
Meldonium | 76144-81-5 | sc-207887 | 100 mg | $455.00 | 1 | |
Meldonium inhibits gamma-butyrobetaine hydroxylase, leading to decreased synthesis of carnitine. As carnitine is a substrate for OCTL2, reduced availability leads to decreased OCTL2 transport activity. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $34.00 $79.00 $179.00 | 3 | |
High concentrations of L-Carnitine can inhibit OCTL2 by substrate inhibition, where the excess substrate itself diminishes the transport efficiency of the protein. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
1,1-Dimethylbiguanide, Hydrochloride is known to inhibit mitochondrial complex I, which can lead to altered cellular energy status and indirectly impact OCTL2 function by decreasing the demand for carnitine transport necessary for fatty acid oxidation. | ||||||
Pyruvic acid | 127-17-3 | sc-208191 sc-208191A | 25 g 100 g | $41.00 $96.00 | ||
Pyruvate, by serving as an alternative energy source and enhancing glycolysis, reduces the requirement for fatty acid oxidation and thus can indirectly lead to a decrease in OCTL2 activity as the cellular demand for carnitine transport diminishes. | ||||||
Trimetazidine Dihydrochloride | 13171-25-0 | sc-220334 | 10 mg | $213.00 | ||
Trimetazidine inhibits fatty acid beta-oxidation, which reduces the requirement for carnitine and, by extension, the transport function of OCTL2. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Nicotinic acid can inhibit lipolysis, leading to reduced levels of free fatty acids for oxidation. This leads to a decreased need for carnitine transport by OCTL2, as fatty acid oxidation is diminished. | ||||||
(+)-Etomoxir sodium salt | 828934-41-4 | sc-215009 sc-215009A | 5 mg 25 mg | $151.00 $506.00 | 3 | |
Etomoxir inhibits carnitine palmitoyltransferase 1 (CPT1), thereby reducing fatty acid entry into mitochondria for oxidation. This results in a decreased functional need for OCTL2-mediated carnitine transport. | ||||||
Ranolazine | 95635-55-5 | sc-212769 | 1 g | $109.00 | 3 | |
Ranolazine inhibits fatty acid beta-oxidation, consequently decreasing the requirement for carnitine transport and indirectly leading to reduced OCTL2 activity. | ||||||