Oct-6 Inhibitors
Oct-6 Inhibitors encompass a range of chemical compounds designed to downregulate or inhibit the activity of Oct-6, a transcription factor crucial for the regulation of various cellular processes, including myelination in the nervous system. These inhibitors act through both direct and indirect mechanisms to modulate Oct-6 expression and function. Direct inhibitors of Oct-6, such as Trichostatin A, Vorinostat (SAHA), and Valproic Acid, operate by inhibiting histone deacetylase (HDAC) activity. By doing so, they promote histone acetylation, leading to changes in chromatin structure that negatively impact Oct-6 expression. This direct inhibition is essential for studying Oct-6's role in transcriptional regulation and its downstream effects on myelination.
On the other hand, indirect Oct-6 inhibitors, including SB431542, LY364947, SB203580, PD98059, SP600125, RepSox, LY2109761, SIS3, and XAV939, influence Oct-6 expression by targeting specific signaling pathways. For example, compounds like SB431542 and RepSox block the TGF-β signaling pathway, which is known to activate Oct-6 transcription. Similarly, inhibitors like SB203580 and PD98059 target MAPK signaling pathways, while SP600125 inhibits the JNK pathway, all of which indirectly downregulate Oct-6 by interfering with critical downstream signaling events. In conclusion, Oct-6 Inhibitors represent a valuable toolset for researchers studying the regulatory mechanisms of Oct-6 and its impact on myelination and other cellular processes. Whether through direct histone modification or indirect pathway modulation, these chemicals contribute to a better understanding of Oct-6's role in gene expression and its implications in neurological development and diseases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a direct inhibitor of Oct-6. It inhibits histone deacetylase (HDAC) activity, leading to increased histone acetylation and altered chromatin structure, thereby downregulating Oct-6 expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid, also known as SAHA, is a direct inhibitor of Oct-6. It functions as an HDAC inhibitor, promoting histone acetylation and influencing Oct-6 expression by modulating chromatin remodeling. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid is a direct inhibitor of Oct-6. It inhibits histone deacetylase (HDAC) activity, resulting in enhanced histone acetylation and altered chromatin structure, leading to Oct-6 downregulation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is an indirect Oct-6 inhibitor. It blocks the TGF-β signaling pathway, indirectly modulating Oct-6 by preventing TGF-β-mediated transcriptional activation and downstream signaling. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $105.00 $153.00 | 4 | |
LY364947 is an indirect inhibitor of Oct-6. It inhibits the TGF-β signaling pathway, indirectly downregulating Oct-6 expression by interfering with TGF-β-mediated transcriptional events. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an indirect Oct-6 inhibitor. It targets the p38 MAPK signaling pathway, indirectly modulating Oct-6 expression by inhibiting p38-mediated transcriptional activation and downstream signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an indirect inhibitor of Oct-6. It inhibits the MAPK/ERK signaling pathway, indirectly downregulating Oct-6 by preventing MAPK/ERK-mediated transcriptional events and signaling cascades. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an indirect Oct-6 inhibitor. It targets the JNK signaling pathway, indirectly modulating Oct-6 expression by inhibiting JNK-mediated transcriptional activation and downstream signaling. | ||||||
ALK5 Inhibitor II | 446859-33-2 | sc-221234 sc-221234A sc-221234B sc-221234C sc-221234D sc-221234E sc-221234F | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $75.00 $150.00 $215.00 $650.00 $1224.00 $4296.00 $7818.00 | 8 | |
ALK5 Inhibitor II (RepSox) is an indirect inhibitor of Oct-6. It blocks the TGF-β signaling pathway, indirectly downregulating Oct-6 by preventing TGF-β-mediated transcriptional activation and downstream signaling. | ||||||
LY2109761 | 700874-71-1 | sc-396262 sc-396262A | 1 mg 5 mg | $87.00 $270.00 | 9 | |
LY2109761 is an indirect Oct-6 inhibitor. It inhibits the TGF-β signaling pathway, indirectly modulating Oct-6 by interfering with TGF-β-mediated transcriptional events and downstream signaling. | ||||||