OBSL1 Activators
OBSL1 Activators are a diverse set of chemical compounds that indirectly enhance the activity of OBSL1 by modulating various signaling pathways or cellular processes. These compounds act on different targets such as IP3 receptors, intracellular calcium, cAMP levels, GSK-3β, PI3K, mTOR, TRPV1, NF-κB, PKA, and CaMKII, inhibiting their activity and thereby, reducing the activation and synthesis of phosphatases that can oppose OBSL1. Some examples include 2-APB and BAPTA-AM that reduce calcium signaling and increase OBSL1 activity by limiting the activation of calcium-dependent phosphatases. Similarly, Theophylline and ZM-241385 manipulate cAMP levels to inhibit phosphatases that oppose OBSL1.
Further, compounds like Indirubin-3'-monoxime, LY294002, and Rapamycin target protein kinases such as GSK-3β, PI3K, and mTOR respectively, preventing the activation and synthesis of phosphatases that can dephosphorylate the substrates of OBSL1. Capsaicin enhances OBSL1 activity by activating calcium-dependent kinases that inhibit phosphatases opposing OBSL1. Sanguinarine and H-89 limit the transcription and phosphorylation of phosphatases, respectively, which can oppose OBSL1, thereby enhancing its function. In addition, Oleuropein, an antioxidant, preserves OBSL1's function by reducing oxidative stress, and KN-62, a CaMKII inhibitor, prevents the activation of phosphatases that can oppose OBSL1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB is an IP3 receptor antagonist that blocks calcium channels and reduces calcium influx. Reduced calcium signaling can increase the activity of OBSL1, as it limits the activation of calcium-dependent phosphatases that can act in opposition to OBSL1. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a chelator of intracellular calcium and inhibits the activation of calcium-dependent phosphatases. By inhibiting these phosphatases, BAPTA-AM can enhance the activity of OBSL1. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $32.00 $85.00 | 6 | |
Theophylline is a phosphodiesterase (PDE) inhibitor that increases cAMP levels and subsequently activates PKA. The activated PKA can phosphorylate and inhibit phosphatases that oppose OBSL1, thus enhancing its activity. | ||||||
ZM 241385 | 139180-30-6 | sc-361421 sc-361421A | 5 mg 25 mg | $92.00 $356.00 | 1 | |
ZM-241385 is a selective antagonist of the A2A adenosine receptor and its action can prevent the rise in cAMP levels and subsequent activation of PKA, thereby enhancing OBSL1's activity. | ||||||
Indirubin-3′-monoxime | 160807-49-8 | sc-202660 sc-202660A sc-202660B | 1 mg 5 mg 50 mg | $79.00 $321.00 $671.00 | 1 | |
Indirubin-3'-monoxime is an inhibitor of GSK-3β. By inhibiting this kinase, it reduces the activation and synthesis of phosphatases that can dephosphorylate substrates of OBSL1, leading to enhanced OBSL1 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can reduce the activation and synthesis of phosphatases opposing OBSL1. By limiting the action of these phosphatases, OBSL1 activity is enhanced. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor that prevents the activation and synthesis of phosphatases opposed to OBSL1. By inhibiting these phosphatases, Rapamycin can enhance OBSL1 activity. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin is a TRPV1 agonist that increases calcium influx. This elevated calcium levels can activate calcium-dependent kinases that phosphorylate and inhibit phosphatases opposing OBSL1, thereby enhancing OBSL1 activity. | ||||||
Sanguinarium | 2447-54-3 | sc-473396 | 10 mg | $220.00 | ||
Sanguinarium is an inhibitor of NF-κB. It prevents the transcription of phosphatases opposed to OBSL1, thus enhancing OBSL1's function. | ||||||
Oleuropein | 32619-42-4 | sc-286622 sc-286622A sc-286622B sc-286622C | 500 mg 1 g 10 g 100 g | $359.00 $530.00 $791.00 $6773.00 | 2 | |
Oleuropein is an antioxidant that reduces oxidative stress and thus preserves OBSL1's function by reducing the activation of stress-responsive phosphatases that can inhibit OBSL1. | ||||||