Oatp4 Inhibitors
Oatp4 inhibitors belong to a distinct chemical class that primarily targets the organic anion-transporting polypeptide 4 (Oatp4) membrane transporter proteins, thereby modulating the cellular uptake of various substances. The Oatp4 proteins are integral components of the solute carrier family, specifically belonging to the SLCO gene family, and are renowned for their involvement in the transportation of a diverse array of endogenous and exogenous compounds across cell membranes. These transporters play a pivotal role in the absorption, distribution, and elimination of numerous substrates, including hormones, drugs, and xenobiotics, by facilitating their movement across biological barriers.
The inhibitors of Oatp4 are characterized by their ability to selectively impede the function of these transporters, thereby altering the normal cellular transport processes. Structurally, Oatp4 inhibitors possess distinct molecular features that enable them to interact with specific binding sites on the Oatp4 proteins, disrupting their usual transport activities. By doing so, these inhibitors exert influence over the cellular dynamics of various compounds, potentially impacting their pharmacokinetics and bioavailability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin is an antibiotic that can inhibit OATP4 by interacting with the substrate binding site and blocking the transport of other substrates. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporine A is an immunosuppressant that can inhibit OATP4 by blocking its substrate transport function. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $56.00 $240.00 $815.00 $1305.00 | 4 | |
Erythromycin is an antibiotic that can inhibit OATP4 by binding to the substrate site preventing the transport of other substrates. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is a calcium channel blocker that can inhibit OATP4 by competing for the substrate binding site. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker that can block OATP4 by interacting with the substrate binding site and preventing the transport of other substrates. | ||||||
Fexofenadine | 83799-24-0 | sc-218475 | 100 mg | $292.00 | 1 | |
Fexofenadine is an antihistamine that can inhibit OATP4 by competing with other substrates for the substrate binding site. | ||||||
Quinidine | 56-54-2 | sc-212614 | 10 g | $102.00 | 3 | |
Quinidine is an antiarrhythmic agent that can inhibit OATP4 by binding to the substrate site and blocking the transport of other substrates. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $256.00 | 18 | |
Tamoxifen is an estrogen receptor modulator that can inhibit OATP4 by interacting with the substrate site, preventing the transport of other substrates. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate is an antimetabolite and antifolate drug that can inhibit OATP4 by competing for the substrate binding site. | ||||||
Olmesartan acid | 144689-24-7 | sc-219481 sc-219481A sc-219481B sc-219481C sc-219481D | 10 mg 500 mg 1 g 2 g 5 g | $153.00 $204.00 $326.00 $523.00 $1051.00 | 7 | |
Olmesartan is an angiotensin II receptor antagonist that can inhibit OATP4 by blocking its substrate transport function. | ||||||