Oatp4 Activators
OATP4 Activators encompass a range of compounds that can indirectly influence the activity of OATP4, a crucial membrane transport protein. These activators primarily function by altering cellular signaling pathways and processes that regulate the expression, localization, and function of OATP4. For instance, compounds like cAMP and Forskolin, known for their role in elevating intracellular cAMP levels, can modulate OATP4 activity indirectly by affecting signaling cascades that govern membrane protein dynamics. Similarly, agents like PMA, which activates PKC, can influence OATP4 by altering protein kinase-mediated signaling pathways, impacting membrane protein expression and localization.
Furthermore, hormonal regulators like Glucagon, Insulin, Estrogen, and Progesterone play a significant role in modulating OATP4 activity. These hormones, through their respective receptors and signaling cascades, can influence cellular processes that ultimately affect the functioning of membrane transport proteins like OATP4. Additionally, compounds such as Retinoic Acid and Lithium, known for their wide-ranging effects on cellular signaling and gene expression, can also impact OATP4 activity. These effects are mediated through alterations in gene expression patterns and signaling pathways that are critical for the regulation of membrane protein function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
cAMP is a secondary messenger important in many biological processes. It can modulate the activity of OATP4 indirectly by altering signaling pathways that regulate membrane protein expression and localization. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a labdane diterpene that is a potent activator of the enzyme adenylate cyclase, resulting in increased levels of cAMP. This increase can indirectly affect OATP4 by modulating cellular signaling pathways related to membrane transport. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC). PKC activation can lead to the modulation of transporter proteins like OATP4 through changes in cellular signaling and membrane dynamics. | ||||||
Glucagon trifluoroacetic acid salt | 9007-92-5 (free base) | sc-495801 | 1 mg | $480.00 | ||
Glucagon is a peptide hormone that raises the concentration of glucose in the bloodstream. Its interaction with its receptor can lead to increased cAMP levels, which may indirectly influence OATP4 activity through altered cellular signaling. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is known to affect several signaling pathways. It can indirectly influence OATP4 by altering the balance of secondary messengers and modulating pathways involved in membrane protein regulation. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin is a hormone that regulates metabolism. It can indirectly influence OATP4 activity by modulating signaling pathways that affect membrane protein expression and function. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
β-Estradiol, a steroid hormone, can modulate various cellular processes. It may indirectly affect OATP4 by influencing signaling pathways related to membrane protein regulation and expression. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Progesterone is another steroid hormone that can influence various signaling pathways. It may indirectly affect OATP4 activity by modulating membrane protein expression and trafficking. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, found in Vitamin A, influences cell differentiation and growth. It can indirectly affect OATP4 by modulating gene expression and cellular signaling pathways related to membrane protein function. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $27.00 $2809.00 $129.00 $210.00 $583.00 $88.00 | 11 | |
Cholesterol is integral to cellular membranes and can influence membrane fluidity. It may indirectly modulate OATP4 activity by affecting membrane dynamics and protein localization. | ||||||