Date published: 2026-7-29

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β-Estradiol (CAS 50-28-2)

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Alternate Names:
17β-Estradiol; 17β-Oestradiol; E2; Estradiol; 1,3,5-Estratriene-3,17β-diol
Application:
β-Estradiol is an ER agonist and activator of PI 3-kinase
CAS Number:
50-28-2
Purity:
≥98%
Molecular Weight:
272.38
Molecular Formula:
C18H24O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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β-Estradiol is an endogenous estrogenic hormone receptor (ER) agonist (Ki values are 0.12 and 0.13 nM for ERalpha and ERbeta respectively). Also high affinity ligand at membrane estrogen GPR30 receptors. β-Estradiol is an activator of PI 3-kinase.


β-Estradiol (CAS 50-28-2) References

  1. Controlled release of beta-estradiol from PLAGA microparticles: the effect of organic phase solvent on encapsulation and release.  |  Birnbaum, DT., et al. 2000. J Control Release. 65: 375-87. PMID: 10699296
  2. Tightly regulated, beta-estradiol dose-dependent expression system for yeast.  |  Gao, CY. and Pinkham, JL. 2000. Biotechniques. 29: 1226-31. PMID: 11126125
  3. The effects of beta-estradiol on SHSY5Y neuroblastoma cells during heavy metal induced oxidative stress, neurotoxicity and beta-amyloid secretion.  |  Olivieri, G., et al. 2002. Neuroscience. 113: 849-55. PMID: 12182891
  4. The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases.  |  Itäaho, K., et al. 2008. Drug Metab Dispos. 36: 2307-15. PMID: 18719240
  5. Layer-by-layer assembly of β-estradiol loaded mesoporous silica nanoparticles on titanium substrates and its implication for bone homeostasis.  |  Hu, Y., et al. 2010. Adv Mater. 22: 4146-50. PMID: 20717987
  6. System for stable β-estradiol-inducible gene expression in the moss Physcomitrella patens.  |  Kubo, M., et al. 2013. PLoS One. 8: e77356. PMID: 24086772
  7. Microalgae cultivation on wastewater digestate: β-estradiol and 17α-ethynylestradiol degradation and transformation products identification.  |  Hom-Diaz, A., et al. 2015. J Environ Manage. 155: 106-13. PMID: 25785785
  8. β-Estradiol and ethinyl-estradiol contamination in the rivers of the Carpathian Basin.  |  Avar, P., et al. 2016. Environ Sci Pollut Res Int. 23: 11630-8. PMID: 26936475
  9. Effects of Elevated β-Estradiol Levels on the Functional Morphology of the Testis - New Insights.  |  Leavy, M., et al. 2017. Sci Rep. 7: 39931. PMID: 28045098
  10. beta-Estradiol reduces natural killer cells in mice.  |  Seaman, WE., et al. 1978. J Immunol. 121: 2193-8. PMID: 722074
  11. Beta-estradiol protects hippocampal CA1 neurons against transient forebrain ischemia in gerbil.  |  Sudo, S., et al. 1997. Neurosci Res. 29: 345-54. PMID: 9527626

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

β-Estradiol, 500 mg

sc-204431
500 mg
$63.00

β-Estradiol, 5 g

sc-204431A
5 g
$182.00