OATP-F Inhibitors
The class of compounds referred to as OATP-F inhibitors belong to a distinctive category within the realm of chemical entities. These inhibitors are characterized by their ability to selectively modulate the activity of the organic anion transporting polypeptide-F (OATP-F) transporters. OATP-F transporters are integral membrane proteins that play a pivotal role in the transportation of a diverse range of endogenous and exogenous compounds across cell membranes.
OATP-F inhibitors exert their effect by interacting with these transporters, altering their normal transport functions. The intricate mechanism behind the inhibition involves a complex interplay between the chemical structure of the inhibitors and the structural components of the OATP-F transporters, often involving competitive or non-competitive interactions. This class of inhibitors represents a significant area of interest in scientific research, contributing to a deeper understanding of molecular transport processes and their potential implications.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
An antibiotic commonly used for tuberculosis. It is also known for its strong inhibition of OATP transporters. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Potent inhibitor of various OATPs, affecting substrate transport by altering membrane permeability. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $57.00 $245.00 $831.00 $1331.00 | 4 | |
Acts on OATP transporters by competitive inhibition, disrupting the cellular uptake of endogenous and exogenous compounds. | ||||||
Gemfibrozil | 25812-30-0 | sc-204764 sc-204764A | 5 g 25 g | $66.00 $267.00 | 2 | |
A chemical used to lower lipid levels. It has been shown to inhibit several OATP transporters. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $38.00 | 13 | |
Flavonoid that can inhibit OATP activity, possibly by altering transporter conformation or competing for transport sites. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
Has been shown to inhibit OATP-mediated transport, affecting drug disposition and pharmacokinetics. | ||||||
Glyburide (Glibenclamide) | 10238-21-8 | sc-200982 sc-200982A sc-200982D sc-200982B sc-200982C | 1 g 5 g 25 g 100 g 500 g | $46.00 $61.00 $117.00 $173.00 $530.00 | 36 | |
Sulfonylurea class drug that inhibits OATP transport, impacting glucose regulation processes. | ||||||
Naringin | 10236-47-2 | sc-203443 sc-203443A | 25 g 50 g | $45.00 $101.00 | 7 | |
A flavonoid that exhibits inhibition towards OATP transporters, affecting drug bioavailability and metabolism. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Plant flavonol that inhibits various OATPs, potentially altering the pharmacokinetics of OATP substrates. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Calcium channel blocker that also inhibits OATP function, affecting cellular uptake of certain drugs. | ||||||