OATP-F Antibody (G-5): sc-398883

OATP-F Antibody (G-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects OATP-F protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OATP-F (G-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. OATP-F protein, also known as SLCO1C1 or SLC21A14, is a 712 amino acid multi-pass membrane protein that plays a crucial role in hepatic uptake of organic anions, including thyroid hormones such as thyroxine (T4) and reverse triiodothyronine (rT3). This transport function is vital for maintaining thyroid hormone homeostasis, which is essential for regulating metabolism, growth, and development. OATP-F is predominantly expressed in Leydig cells of testis and brain, highlighting OATP-F′s importance in both reproductive and neurological functions. Additionally, OATP-F is involved in transport of other compounds, such as estrone-3-sulfate and sulfobromophthalein, albeit at lower efficiencies, making OATP-F a significant player in drug metabolism and disposition.

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OATP-F Antibody (G-5) References:

1. An evolutionarily ancient Oatp: insights into conserved functional domains of these proteins.  |  Cai, SY., et al. 2002. Am J Physiol Gastrointest Liver Physiol. 282: G702-10. PMID: 11897630
2. Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter.  |  Pizzagalli, F., et al. 2002. Mol Endocrinol. 16: 2283-96. PMID: 12351693
3. Screening of the interaction between xenobiotic transporters and PDZ proteins.  |  Kato, Y., et al. 2004. Pharm Res. 21: 1886-94. PMID: 15553237
4. Role of organic anion transporting polypeptide 2 in pharmacokinetics of digoxin and beta-methyldigoxin in rats.  |  Funakoshi, S., et al. 2005. J Pharm Sci. 94: 1196-203. PMID: 15858844
5. Thyroid hormone transport and metabolism by organic anion transporter 1C1 and consequences of genetic variation.  |  van der Deure, WM., et al. 2008. Endocrinology. 149: 5307-14. PMID: 18566113
6. Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier.  |  Roberts, LM., et al. 2008. Endocrinology. 149: 6251-61. PMID: 18687783
7. Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs.  |  Westholm, DE., et al. 2009. Endocrinology. 150: 1025-32. PMID: 18845642
8. Pharmacogenetics of the organic anion transporting polypeptide 1A2.  |  Franke, RM., et al. 2009. Pharmacogenomics. 10: 339-44. PMID: 19290786

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-OATP-F Antibody (G-5) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-OATP-F Antibody (G-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

OATP-F Antibody (G-5) Specifications

Alternate Product Name: OATP-F

Product Clone Name: G-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-71

Epitope Target: OATP-F

Epitope Species: mouse

Product Reactivity/Detection: OATP-F

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for OATP-F Antibody (G-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin