NYD-SP17 Activators
NYD-SP17, also known as cation channel sperm-associated protein 4 (CatSper4), is a protein in humans encoded by the CATSPER4 gene. It is part of the CatSper family of proteins, which are voltage-gated calcium channels specifically expressed in the membrane of sperm cells. These proteins are essential for sperm motility and are directly involved in the regulation of sperm hyperactivation, a vigorous form of motility necessary for fertilization.The CatSper complex is composed of multiple subunits, and NYD-SP17 is believed to contribute to the proper function and structure of this complex. While the exact role of NYD-SP17 within the CatSper channel is not entirely clear, it is thought to modulate the channel's activity or affect its localization within the sperm cell.
Calcium influx through CatSper channels is crucial for several aspects of sperm function. It triggers the whip-like motion of the flagellum that propels the sperm towards the egg. This calcium entry is also pivotal during capacitation, a maturation process that sperm undergo in the female reproductive tract, preparing them for the acrosome reaction and subsequent penetration of the egg's outer layers.Mutations in the genes encoding CatSper proteins, including NYD-SP17, can lead to male infertility due to impaired sperm motility. Given its significance in sperm physiology, NYD-SP17 is a potential target for the development of contraceptives that could selectively inhibit CatSper channel activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Involved in gene expression regulation and cellular differentiation, potentially impacting pathways associated with NYD-SP17. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Influences various signaling pathways and gene expression, potentially affecting NYD-SP17. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Affects cell signaling and gene expression, possibly impacting NYD-SP17. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates cAMP signaling, which could impact cellular processes involving NYD-SP17. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Influences various signaling pathways, potentially impacting NYD-SP17 function. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Modulates signaling pathways and gene expression, potentially affecting NYD-SP17. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Influences multiple signaling pathways, potentially affecting NYD-SP17. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Regulates gene expression and cell signaling, possibly affecting NYD-SP17. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Involved in cellular metabolism and signaling, potentially influencing NYD-SP17. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid impacting signaling pathways and gene expression, potentially affecting NYD-SP17. | ||||||