Nup35 Activators
Nup35, also known as nucleoporin 35 or Nup53, is a protein that is a key component of the nuclear pore complex (NPC), which regulates the transport of molecules between the nucleus and the cytoplasm in eukaryotic cells. Nup35 is a non-fibrous, scaffold nucleoporin, which means it contributes to the structural core of the NPC and is involved in anchoring other nucleoporins that form the transport channel.
This protein is involved in several fundamental cellular processes, including nucleocytoplasmic trafficking, gene expression regulation, and the cell cycle. Nup35 interacts with various nuclear transport receptors and plays a role in the bidirectional transport of RNA and proteins across the nuclear envelope. It is also implicated in the assembly and disassembly of the NPC during cell division, ensuring that genetic material and other critical cellular components are accurately shared between daughter cells.Mutations or dysregulation of Nup35 can lead to disruptions in nuclear transport, which may contribute to the development of diseases, including cancer and viral infections, where the integrity of the nuclear transport system is often compromised.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid regulates gene expression and differentiation, potentially affecting Nup35 expression in developing cells. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
This translation inhibitor may lead to compensatory changes in nuclear transport mechanisms, possibly affecting Nup35 levels. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
As an antimetabolite, methotrexate can alter nucleotide synthesis and potentially influence Nup35 expression during DNA replication and repair. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C, which can modulate various cellular processes including gene expression, potentially impacting Nup35. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium affects glycogen synthase kinase-3 (GSK-3) activity, which may influence Nup35 expression through Wnt signaling pathways. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
As a histone deacetylase inhibitor, sodium butyrate can alter gene expression, potentially increasing Nup35 levels. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine affects lysosomal function and autophagy, which might indirectly influence Nup35 expression. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $256.00 | 18 | |
Tamoxifen modulates estrogen receptor activity and could influence gene expression profiles, including Nup35. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Sp1 is a transcription factor; its inhibition could alter the expression of genes including those coding for nuclear pore components. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, potentially affecting Nup35 expression as part of the cellular stress response to misfolded proteins. | ||||||