NSUN7 Inhibitors
The chemical class denoted as NSUN7 Inhibitors encompasses various compounds that target or have the potential to modulate the activity of the NSUN7 protein, an RNA methyltransferase. The exact signaling pathways and comprehensive functionality of NSUN7 are yet to be extensively detailed. However, based on its classification, it's understood that NSUN7 is likely involved in the methylation of cytosine residues within RNA.
Given its functional profile, chemicals such as sinefungin, a potent AdoMet analog, can reduce RNA methylation events by competing with the natural methyl donor AdoMet. On a similar note, adenosine periodate acts by oxidizing adenosine in RNA, subsequently altering the structure and the substrate availability for RNA methyltransferases like NSUN7. Additionally, compounds like 5-Aza-2'-deoxycytidine, RG108, and Decitabine, primarily known for their DNA methyltransferase inhibitory properties, could indirectly influence RNA methylation, hinting at a possible modulatory role on NSUN7. Furthermore, amiloride and amodiaquine, although not exclusive to RNA methyltransferases, showcase inhibitory actions under certain contexts. Overall, the collective actions of these chemicals emphasize the intricate nature of RNA methylation processes and offer a framework for understanding the modulation of NSUN7's function within the cellular environmen
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine, periodate oxidized | 34240-05-6 | sc-214510 sc-214510A | 25 mg 100 mg | $117.00 $357.00 | ||
Alters RNA structure by oxidizing adenosine. The changed RNA structure can influence the substrate availability for RNA methyltransferases, including NSUN7. | ||||||
Sinefungin | 58944-73-3 | sc-203263 sc-203263B sc-203263C sc-203263A | 1 mg 100 mg 1 g 10 mg | $266.00 $5100.00 $39576.00 $690.00 | 4 | |
AdoMet analog that inhibits various methyltransferases. By competing with the methyl donor AdoMet, sinefungin can reduce methylation events on RNA, potentially affecting NSUN7 activity. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
A cytosine analog that incorporates into DNA/RNA and inhibits DNA methyltransferases. It may indirectly affect RNA methylation and NSUN7. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
DNA methyltransferase inhibitor that can indirectly influence the state of RNA methylation by affecting the methylation status of DNA and potentially modulating NSUN7 activity. | ||||||
SANT-1 | 304909-07-7 | sc-203253 | 5 mg | $132.00 | 5 | |
EZH2 inhibitor that targets histone methylation but may have off-target effects on RNA methyltransferases, including NSUN7. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Known to inhibit RNA methyltransferase activity in some contexts, possibly modulating NSUN7's methylation events. | ||||||
5′-Deoxy-5′-methylthioadenosine | 2457-80-9 | sc-202427 | 50 mg | $120.00 | 1 | |
A natural byproduct of polyamine biosynthesis which can inhibit methyltransferase enzymes, potentially influencing NSUN7 activity. | ||||||
Amodiaquine | 86-42-0 | sc-207282 | 10 mg | $342.00 | 1 | |
Antimalarial drug found to inhibit RNA methyltransferases in some conditions. Might modulate NSUN7's enzymatic activity. | ||||||
Procainamide hydrochloride | 614-39-1 | sc-202297 | 10 g | $52.00 | ||
Non-nucleoside inhibitor of DNA methyltransferases. Its role in RNA methylation is less clear, but it might indirectly modulate NSUN7. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $126.00 $278.00 $984.00 | 3 | |
DNA methyltransferase inhibitor that, through altering DNA methylation dynamics, may indirectly impact RNA methylation status and NSUN7 function. | ||||||