NSUN7 Activators
The chemical class known as NSUN7 activators includes a spectrum of compounds that indirectly augment the activity of the methyltransferase NSUN7. These compounds do not interact directly with NSUN7 but enhance its activity by increasing the levels of substrates required for methylation reactions or by modulating co-factor availability. S-Adenosylmethionine (SAMe), the principal donor of methyl groups for methylation processes, is central to NSUN7's activity. Compounds such as folic acid, vitamin B12, and betaine contribute to the production of methionine, which is a precursor of SAMe. Through this contribution, they indirectly enhance NSUN7's activity by ensuring that it has sufficient substrate to carry out methylation.
Additionally, choline and creatine are involved in pathways that generate or consume methyl groups, thus impacting the methylation cycle and possibly affecting NSUN7 activity. Methionine itself, as a direct precursor to SAMe, directly contributes to the pool of available methyl donors within the cell. Vitamins such as riboflavin and pyridoxine are essential for the enzymatic reactions that generate methionine from homocysteine, further influencing the activity of NSUN7. Magnesium and zinc do not directly influence NSUN7 activity but are vital for the structure and function of enzymes that regulate the methylation cycle, which could have downstream effects on NSUN7. Lastly, NAD+ serves as a cofactor for sirtuins, which regulate key metabolic pathways that could intersect with NSUN7's role in methylating nucleic acids, modulating its activity in the cell.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
As a universal methyl group donor, SAMe provides the methyl groups that NSUN7 transfers in methylation reactions. Increased levels of SAMe can enhance the methyltransferase activity of NSUN7 by providing it with more substrate to catalyze its reactions. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Essential for the methionine synthesis pathway, folic acid supplementation can increase the availability of methionine, which is a precursor to S-adenosylmethionine (SAMe), the methyl donor for NSUN7. | ||||||
Vitamin B12 | 68-19-9 | sc-296695 sc-296695A sc-296695B sc-296695C sc-296695D sc-296695E | 100 mg 1 g 5 g 25 g 100 g 1 kg | $60.00 $90.00 $325.00 $1155.00 $3851.00 $10056.00 | 2 | |
Works in conjunction with folic acid to help regenerate methionine from homocysteine, which in turn, supports the synthesis of SAMe, aiding the methyltransferase activity of NSUN7. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $31.00 $41.00 $56.00 $163.00 $337.00 $592.00 | 2 | |
Acts as a methyl donor in the conversion of homocysteine to methionine, thus can indirectly support the generation of SAMe and subsequently, NSUN7's methyltransferase activity. | ||||||
Choline base solution | 123-41-1 | sc-239545 | 100 ml | $79.00 | ||
Can be oxidized to betaine, which donates a methyl group to homocysteine to form methionine, which is then used to produce SAMe, the substrate for NSUN7. | ||||||
Creatine, anhydrous | 57-00-1 | sc-214774 sc-214774A | 10 mg 50 g | $28.00 $79.00 | 2 | |
Its synthesis consumes SAMe as a methyl donor, which may indirectly enhance the demand for SAMe regeneration, potentially increasing NSUN7 activity as the body compensates by increasing SAMe production. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $37.00 $57.00 $151.00 $577.00 $1103.00 | ||
Direct precursor of S-adenosylmethionine (SAMe), supplementation with methionine can raise the levels of SAMe in the cell, thus can potentially increase the activity of NSUN7. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $41.00 $112.00 $525.00 | 3 | |
As a component of the FAD coenzyme, it's essential for the metabolism of homocysteine and the synthesis of methionine, which indirectly supports the production of SAMe and NSUN7 activity. | ||||||
Pyridoxine Hydrochloride | 58-56-0 | sc-219674 | 10 mg | $42.00 | ||
Coenzyme in the synthesis of methionine from homocysteine, thus influencing the availability of SAMe for NSUN7 catalytic activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
It acts as a cofactor for many enzymes, including those involved in nucleic acid metabolism, and might indirectly enhance NSUN7 activity by stabilizing the molecular structure or enhancing substrate binding. | ||||||