NSUN5 Inhibitors
NSUN5 inhibitors belong to a class of chemical compounds that target the enzymatic activity of the NSUN5 protein, a methyltransferase involved in RNA modification. NSUN5, or NOP2/Sun domain family, member 5, is a member of the RNA methyltransferase family, which plays a crucial role in the post-transcriptional modification of RNA molecules. Specifically, NSUN5 is responsible for catalyzing the methylation of cytosine at the 3782 position in the anticodon loop of mitochondrial tRNAs. This modification is essential for maintaining the stability and proper functioning of mitochondrial tRNAs, which are pivotal for the translation of mitochondrial genes. Inhibiting the activity of NSUN5 disrupts this methylation process, potentially leading to altered RNA functionality and impacting cellular processes dependent on accurate mitochondrial protein synthesis.
NSUN5 inhibitors represent a growing area of interest in molecular biology and pharmacology. Researchers are actively exploring these compounds as tools to investigate the biological consequences of NSUN5 inhibition and to unravel the intricate network of RNA modifications. Understanding the precise mechanisms by which NSUN5 inhibitors affect RNA modification can provide valuable insights into the regulation of mitochondrial gene expression and cellular homeostasis. Moreover, these inhibitors may serve as probes for elucidating the broader role of RNA modifications in cellular processes and may open avenues for the development of novel strategies to modulate RNA function for various research applications.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine, periodate oxidized | 34240-05-6 | sc-214510 sc-214510A | 25 mg 100 mg | $117.00 $357.00 | ||
Inhibits S-adenosylhomocysteine hydrolase, increasing levels of S-adenosylhomocysteine which competes with SAM and can reduce methylation reactions. | ||||||
Sinefungin | 58944-73-3 | sc-203263 sc-203263B sc-203263C sc-203263A | 1 mg 100 mg 1 g 10 mg | $266.00 $5100.00 $39576.00 $690.00 | 4 | |
A SAM analog that can inhibit methyltransferases by occupying the SAM binding site. | ||||||
5′-Deoxy-5′-methylthioadenosine | 2457-80-9 | sc-202427 | 50 mg | $120.00 | 1 | |
5'-Methylthioadenosine can act as a product inhibitor for methyltransferases. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
A non-nucleoside DNA methyltransferase inhibitor that may also inhibit RNA methyltransferases. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 free base | sc-202651 | 5 mg | $148.00 | 4 | |
Initially discovered as a G9a histone methyltransferase inhibitor, its mechanism may extend to RNA methyltransferases. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $120.00 | 5 | |
A histone methyltransferase inhibitor that might non-specifically inhibit other methyltransferases. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
A cytidine analog that can be incorporated into RNA and may inhibit RNA methyltransferases. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A nucleoside analog of cytidine that can be incorporated into RNA, potentially inhibiting RNA methylation. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $126.00 $278.00 $984.00 | 3 | |
A cytidine deaminase inhibitor that may also affect RNA methylation by increasing RNA substrate modifications. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
A flavonoid that can inhibit a broad range of protein kinases and may non-specifically affect protein interactions with NSUN5. | ||||||