NSE1 Activators
The chemical class of NSE1 Activators includes compounds that can indirectly influence NSE1 function through their effects on DNA replication stress, DNA damage response, and DNA repair pathways. NSE1, as part of the SMC5/SMC6 complex, plays a significant role in maintaining genomic stability and responding to DNA damage. Compounds such as Hydroxyurea, Mitomycin C, Cisplatin, Etoposide, Doxorubicin, and Camptothecin can induce DNA damage or replication stress, potentially impacting NSE1 activity. The response to DNA damage and replication stress often involves activation of DNA repair mechanisms, in which NSE1 plays a crucial role.
Other agents that affect DNA synthesis and repair, such as Aphidicolin, Bleomycin, 5-Fluorouracil, Gemcitabine, and Olaparib, could also indirectly influence NSE1. These compounds can lead to situations where DNA repair is necessary, potentially involving the SMC5/SMC6 complex and NSE1.Furthermore, inhibitors of DNA damage response kinases like ATR inhibitors can modulate the cellular response to DNA damage and replication stress, potentially affecting NSE1 activity.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Inhibits ribonucleotide reductase, causing replication stress, potentially affecting NSE1 in DNA repair pathways. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Causes DNA crosslinks, potentially inducing DNA damage response and influencing NSE1 activity. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Forms DNA adducts, leading to DNA damage, potentially impacting NSE1 activity in DNA repair. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Inhibits DNA topoisomerase II, causing DNA damage and potentially affecting NSE1 in repair pathways. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Induces DNA damage, possibly influencing NSE1 in DNA repair mechanisms. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
Inhibits DNA polymerases, inducing replication stress which could affect NSE1 activity. | ||||||
Bleomycin Sulfate | 9041-93-4 | sc-200134 sc-200134A sc-200134B sc-200134C | 10 mg 50 mg 100 mg 500 mg | $210.00 $624.00 $1040.00 $2913.00 | 38 | |
Causes DNA breaks, potentially affecting NSE1 activity in DNA repair. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Inhibits DNA topoisomerase I, leading to replication stress that could impact NSE1. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
A pyrimidine analog, affects DNA synthesis, potentially influencing NSE1. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
A nucleoside analog, can impact DNA synthesis, indirectly affecting NSE1. | ||||||