NSD2 Activators
The chemical class of NSD2 Activators includes compounds that can indirectly influence NSD2 function through their effects on chromatin remodeling, gene expression, and cellular stress responses. NSD2, as a histone methyltransferase, plays a critical role in modulating chromatin structure and gene expression regulation. HDAC inhibitors such as Trichostatin A, Valproic Acid, Sodium Butyrate, Vorinostat, and others, by altering chromatin dynamics and gene expression patterns, can potentially modulate NSD2 activity. These inhibitors affect chromatin structure, which is crucial for the regulation of proteins involved in chromatin remodeling, including NSD2.
Compounds that influence gene expression and cellular differentiation, such as Retinoic Acid and Genistein, might modulate the expression of genes regulated by or coding for NSD2, thereby influencing its function. Additionally, natural compounds with various biological activities like Curcumin, Resveratrol, EGCG, and Sulforaphane can influence cellular signaling pathways and stress responses, potentially modulating NSD2 activity. Furthermore, Lithium Chloride, a GSK-3 inhibitor, by impacting key cellular signaling pathways, can have downstream effects on NSD2 function. Modulating these signaling pathways could indirectly affect the activity of NSD2 in the context of chromatin remodeling and gene regulation.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor, potentially impacting gene expression and indirectly affecting NSD2 function. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
An HDAC inhibitor, affects chromatin structure and gene expression, potentially influencing NSD2. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
An HDAC inhibitor, could influence NSD2 activity by affecting gene expression and chromatin dynamics. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
As an HDAC inhibitor, can impact gene expression, potentially modulating NSD2 activity. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Another HDAC inhibitor, might affect NSD2 by altering chromatin remodeling and gene expression patterns. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Influences gene expression and cellular differentiation, potentially impacting NSD2 function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Known for its anti-inflammatory properties, might influence NSD2 function through cellular stress response pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Affects sirtuin pathways, potentially modulating NSD2 activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
A tyrosine kinase inhibitor; suggested to influence chromatin remodeling and gene expression, potentially affecting NSD2. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Found in green tea; suggested to have a stabilizing effect on chromatin structure, potentially affecting NSD2. | ||||||