Nrdp1 Inhibitors
Nrdp1 inhibitors constitute a diverse class of compounds that modulate the activity of Neural Precursor Cell Expressed, Developmentally Down-Regulated 1 (Nrdp1), an E3 ubiquitin ligase involved in the regulation of various cellular processes. These inhibitors act either directly on Nrdp1 or indirectly through the modulation of specific signaling pathways and cellular processes. The following paragraphs provide a detailed exploration of the mechanisms through which these inhibitors influence Nrdp1 and their potential implications in cellular contexts. Nutlin-3 represents an indirect inhibitor of Nrdp1 by stabilizing p53. This stabilization occurs through disruption of the interaction between p53 and MDM2, leading to the accumulation of p53. Activated p53, in turn, transcriptionally regulates downstream genes, including p21, a cyclin-dependent kinase inhibitor. The upregulation of p21 can indirectly modulate Nrdp1 by inhibiting cyclin-dependent kinases, impacting cell cycle progression. SP600125 serves as an indirect Nrdp1 inhibitor by targeting the JNK signaling pathway. By selectively inhibiting JNK, SP600125 disrupts the activation of this kinase, known to phosphorylate and activate Nrdp1.
PD98059 indirectly influences Nrdp1 by targeting the MAPK/ERK pathway. As a MEK inhibitor, PD98059 disrupts the phosphorylation and activation of ERK, a kinase implicated in the regulation of Nrdp1. By inhibiting the MAPK/ERK pathway, PD98059 provides an indirect means of modulating Nrdp1 activity, potentially impacting its stability and function in cellular contexts associated with p38 MAPK signaling. Bortezomib indirectly influences Nrdp1 by targeting the proteasome. As a proteasome inhibitor, bortezomib prevents the degradation of ubiquitinated proteins, including Nrdp1. SB203580 indirectly influences Nrdp1 through the p38 MAPK pathway. As a p38 MAPK inhibitor, SB203580 disrupts the activation of p38 MAPK, a kinase involved in the regulation of Nrdp1. Trichostatin A influences Nrdp1 through histone deacetylase (HDAC) inhibition. By inhibiting HDAC, trichostatin A affects the acetylation status of histones, influencing chromatin structure and gene expression. Nrdp1 expression may be influenced by changes in chromatin structure, providing an indirect means through which trichostatin A can modulate Nrdp1 levels and potentially impact cellular processes associated with Nrdp1 function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(–)-Nutlin-3 | 675576-98-4 | sc-222086 sc-222086A | 1 mg 5 mg | $120.00 $215.00 | 2 | |
Nutlin-3 inhibits Nrdp1 indirectly by stabilizing p53. It disrupts the interaction between p53 and MDM2, leading to the accumulation of p53 and subsequent transcriptional activation of downstream genes, including p21. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits Nrdp1 by targeting the JNK signaling pathway. As a selective JNK inhibitor, SP600125 prevents the activation of JNK, a kinase known to phosphorylate and activate Nrdp1. By inhibiting JNK, SP600125 can modulate the phosphorylation status of Nrdp1 and potentially impact its stability and function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin influences Nrdp1 through modulation of the Nrf2 pathway. By activating Nrf2, curcumin induces the expression of antioxidant response genes. Nrf2 has been implicated in the regulation of Nrdp1, and alterations in Nrf2 activity can impact Nrdp1 levels. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 inhibits Nrdp1 indirectly by targeting the proteasome. As a proteasome inhibitor, MG-132 prevents the degradation of ubiquitinated proteins, including Nrdp1. This leads to the accumulation of ubiquitinated Nrdp1, influencing its cellular levels and potentially affecting its function. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin influences Nrdp1 indirectly by affecting cellular stress responses. Cisplatin induces DNA damage and activates p53, a known regulator of Nrdp1. Activated p53 can transcriptionally regulate Nrdp1, leading to changes in its expression levels. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
MLN4924 indirectly modulates Nrdp1 by inhibiting NEDDylation. MLN4924 is a selective inhibitor of NEDD8-activating enzyme (NAE), preventing the activation of NEDD8, a ubiquitin-like modifier. Since Nrdp1 undergoes NEDDylation, inhibiting this process with MLN4924 can impact the ubiquitination and stability of Nrdp1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 influences Nrdp1 through the PI3K/AKT pathway. As a PI3K inhibitor, LY294002 disrupts the activation of AKT, a kinase involved in the regulation of Nrdp1. AKT-mediated phosphorylation can affect the stability and function of Nrdp1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin indirectly influences Nrdp1 through mTOR signaling. As an mTOR inhibitor, rapamycin disrupts mTORC1 activity, which can impact various cellular processes, including protein degradation pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 influences Nrdp1 by targeting the MAPK/ERK pathway. As a MEK inhibitor, PD98059 disrupts the phosphorylation and activation of ERK, a kinase implicated in the regulation of Nrdp1. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib indirectly influences Nrdp1 by targeting the proteasome. As a proteasome inhibitor, bortezomib prevents the degradation of ubiquitinated proteins, including Nrdp1. | ||||||