NrCAM Inhibitors
Chemical inhibitors of NrCAM can exert their inhibitory effects through various mechanisms, impacting different signaling pathways and cellular processes that NrCAM is involved in. L-NAME, for instance, inhibits nitric oxide synthase, which plays a regulatory role in axonal growth and guidance-a process where NrCAM is also crucial. By inhibiting nitric oxide production, L-NAME alters the cytoskeletal dynamics that NrCAM is a part of, thus impeding NrCAM's functional role in neurite outgrowth. Similarly, PP2, an Src family kinase inhibitor, hinders the phosphorylation of NrCAM, which is vital for its function in neuronal growth cone guidance. The inhibition of Src kinases by PP2, therefore, disrupts NrCAM's participation in signaling cascades that are essential for neuronal development.
LY294002 and U0126 target the PI3K and MEK/ERK pathways, respectively. LY294002, a PI3K inhibitor, disrupts the stabilization of NrCAM in the neuronal membrane and its interaction with the cytoskeleton, thereby reducing NrCAM's role in neuronal signaling. U0126, by inhibiting MEK, impairs the downstream ERK pathway, which influences the function of cell adhesion molecules like NrCAM. SB203580, SP600125, and NSC23766 address other kinases and GTPases involved in NrCAM's functional pathways. SB203580, as a p38 MAP kinase inhibitor, and SP600125, as a JNK inhibitor, hamper the cytoskeletal dynamics and cell adhesion processes in which NrCAM is involved. NSC23766, by inhibiting Rac1, disrupts NrCAM's role in Rac1-dependent cytoskeletal rearrangement. BAPTA-AM, Go6983, and W7 Hydrochloride interfere with calcium signaling and calmodulin, respectively. BAPTA-AM chelates intracellular calcium critical for NrCAM's role in synaptogenesis, while Go6983 inhibits PKC, which regulates NrCAM. W7 Hydrochloride, by antagonizing calmodulin, disrupts its interaction with NrCAM, affecting calcium-dependent signaling processes. Lastly, Y-27632, a ROCK inhibitor, impedes NrCAM's role in neurite outgrowth and neuronal migration by inhibiting ROCK-dependent signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-NG-Nitroarginine Methyl Ester (L-NAME) | 51298-62-5 | sc-200333 sc-200333A sc-200333B | 1 g 5 g 25 g | $47.00 $105.00 $322.00 | 45 | |
L-NAME is a nitric oxide synthase inhibitor that can inhibit neuronal nitric oxide synthase (nNOS), which is involved in the regulation of axonal growth and guidance where NrCAM also plays a role; inhibition of nNOS can alter cytoskeletal dynamics that NrCAM is a part of, thus inhibiting NrCAM's functional role in neurite outgrowth. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an Src family kinase inhibitor; Src kinases can phosphorylate NrCAM and are important for its function in neuronal growth cone guidance, so inhibition of Src kinases by PP2 can inhibit NrCAM's function in signaling cascades essential for neuronal development. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor; PI3K signaling is important for the stabilization of NrCAM in the neuronal membrane and its interaction with the cytoskeleton, so inhibition by LY294002 can reduce NrCAM's functional role in neuronal signaling. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor; MEK is upstream of ERK, which can influence the expression and function of cell adhesion molecules like NrCAM, so U0126 can inhibit NrCAM-mediated signaling that relies on the MEK/ERK pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor; p38 MAPK can influence the cytoskeletal dynamics and cell adhesion processes involving NrCAM, so inhibition by SB203580 can disrupt NrCAM's role in these processes. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor; JNK pathway is involved in neurite outgrowth and can cross-talk with NrCAM signaling pathways, so inhibition by SP600125 can inhibit NrCAM's role in the JNK-dependent neurite outgrowth. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM is an intracellular calcium chelator; NrCAM's function as a cell adhesion molecule in synaptic formation is calcium-dependent, so reduction of intracellular calcium by BAPTA-AM can inhibit NrCAM's functional role in synaptogenesis. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Go6983 is a protein kinase C (PKC) inhibitor; PKC has been implicated in the regulation of cell adhesion molecules like NrCAM, so inhibition by Go6983 can inhibit NrCAM's role in PKC-mediated signal transduction involved in neuronal guidance. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
W7 Hydrochloride is a calmodulin antagonist; calmodulin interacts with cell adhesion molecules and is involved in the calcium-signaling pathways that can regulate NrCAM, so inhibition by W7 Hydrochloride can inhibit NrCAM's function in calcium-dependent signaling processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an ERK pathway inhibitor; it inhibits MEK which in turn prevents ERK activation, a pathway that can regulate NrCAM localization and function, so inhibition by PD98059 can inhibit NrCAM's role in ERK-mediated signaling in neurons. | ||||||