NR3B Activators
NR3B activators are a category of chemical compounds that interact with the NR3B subunit, also known as GluN3B, which is a component of the N-methyl-D-aspartate receptor (NMDAR) complex. NMDARs are ionotropic glutamate receptors that play a crucial role in synaptic transmission and plasticity in the central nervous system. The receptor complex is a heterotetramer, usually composed of two obligatory GluN1 subunits and two regulatory subunits which can include GluN2 (A-D) and GluN3 (A-B) subunits. The inclusion of the NR3B subunit in this complex can modulate the receptor's ion channel properties. NR3B activators, therefore, influence the activity of the receptors by selectively binding to the NR3B subunit, which can alter the receptor's pharmacology, kinetics, and calcium permeability. The precise mechanism by which NR3B activators modulate the receptor function is complex and involves the alteration of NMDAR subunit composition and the consequent functional dynamics of the receptor.
The chemistry of NR3B activators is diverse, reflecting a range of structures that can engage with the NR3B subunit. The interaction between the activators and the receptor is highly specific, often involving direct binding to the modulatory sites distinct from the glutamate-binding site. These activators can be either synthetic or naturally occurring compounds, and they can vary greatly in terms of their molecular size, polarity, and overall shape. Their specificity for the NR3B subunit is of particular interest in the study of the pharmacological modulation of NMDARs because it allows for selective targeting of receptor subtypes with different subunit compositions. By modulating the activity of the NR3B subunit, these activators can affect the ion channel properties of the NMDARs, which in turn can influence the receptor's role in synaptic signaling. The development of NR3B activators contributes significantly to the understanding of the complex pharmacology of NMDARs and the structural-functional relationships within the receptor complexes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $41.00 $71.00 $112.00 $357.00 | 15 | |
Glycine acts as a co-agonist of NMDA receptors, which may contain NR3B subunits. Binding of glycine enhances the receptor's ion channel activity. | ||||||
D-Serine | 312-84-5 | sc-391671 sc-391671A sc-391671B | 5 g 25 g 100 g | $43.00 $128.00 $204.00 | ||
D-Serine is another co-agonist for NMDA receptors and can enhance the receptor activity by binding to the glycine site, potentially involving NR3B. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine can potentiate NMDA receptor activity by interacting with sites that may be modulated by the NR3B subunit, enhancing calcium permeability. | ||||||
Ifenprodil hemitartrate | 23210-58-4 | sc-203601B sc-203601 sc-203601A | 5 mg 10 mg 50 mg | $39.00 $61.00 $142.00 | ||
Ifenprodil selectively inhibits NR2B-containing NMDA receptors, which can lead to compensation by NR3B-containing receptors, indirectly enhancing their activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc can modulate the activity of NMDA receptors by binding to a specific site, which may influence the activity of receptors containing NR3B. | ||||||
Cyclothiazide | 2259-96-3 | sc-202560 sc-202560A | 10 mg 50 mg | $107.00 $227.00 | 3 | |
Cyclothiazide, by preventing AMPA receptor desensitization, can increase synaptic glutamate, which may enhance NR3B-containing NMDA receptor activity. | ||||||
Memantine hydrochloride | 41100-52-1 | sc-203628 | 50 mg | $69.00 | 4 | |
Memantine acts as an uncompetitive NMDA receptor antagonist with voltage-dependent block, which might lead to downstream regulatory effects on NR3B activity. | ||||||
Pregnenolone | 145-13-1 | sc-204860 sc-204860A sc-204860B sc-204860C | 5 g 25 g 100 g 500 g | $87.00 $148.00 $347.00 $1122.00 | ||
Pregnenolone sulfate is a neurosteroid that can modulate NMDA receptor activity, potentially affecting NR3B subunit function. | ||||||