Molecular structure of Cyclothiazide, CAS Number: 2259-96-3
Cyclothiazide (CAS 2259-96-3)
See product citations (3)
Alternate Names:
6-Chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2-4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Application:
Cyclothiazide is a potent inhibitor of desensitization of AMPA receptors
CAS Number:
2259-96-3
Purity:
≥98%
Molecular Weight:
389.88
Molecular Formula:
C14H16ClN3O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Cyclothiazide potently inhibits the desensitization of AMPA receptors. Cyclothiazide acts as a positive allosteric modulator of AMPA receptors that potently inhibit AMPA receptor desensitization. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4. Cyclothiazide is an inhibitor of GABA Receptor.
Cyclothiazide (CAS 2259-96-3) References
- Cyclothiazide prolongs low [Mg2+]-induced seizure-like events. | Lasztóczi, B. and Kardos, J. 2006. J Neurophysiol. 96: 3538-44. PMID: 16914619
- Cyclothiazide: a subunit-specific inhibitor of GABAC receptors. | Xie, A., et al. 2008. J Physiol. 586: 2743-52. PMID: 18420703
- Cyclothiazide induces seizure behavior in freely moving rats. | Kong, S., et al. 2010. Brain Res. 1355: 207-13. PMID: 20678492
- Cyclothiazide-induced persistent increase in respiratory-related activity in vitro. | Babiec, WE., et al. 2012. J Physiol. 590: 4897-915. PMID: 22753547
- Interactions among GYKI-52466, cyclothiazide, and aniracetam at recombinant AMPA and kainate receptors. | Johansen, TH., et al. 1995. Mol Pharmacol. 48: 946-55. PMID: 7476926
- Cyclothiazide potentiates agonist responses at human AMPA/kainate receptors expressed in oocytes. | Sharp, RL., et al. 1994. Eur J Pharmacol. 266: R1-2. PMID: 7511109
- Cyclothiazide acts at a site on the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor complex that does not recognize competitive or noncompetitive AMPA receptor antagonists. | Desai, MA., et al. 1995. J Pharmacol Exp Ther. 272: 38-43. PMID: 7529311
- Cyclothiazide modulates AMPA receptor-mediated increases in intracellular free Ca2+ and Mg2+ in cultured neurons from rat brain. | Hoyt, KR., et al. 1995. J Neurochem. 64: 2049-56. PMID: 7536804
- Desensitization of AMPA receptors upon multiquantal neurotransmitter release. | Trussell, LO., et al. 1993. Neuron. 10: 1185-96. PMID: 7686382
- Differential modulation by cyclothiazide and concanavalin A of desensitization at native alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and kainate-preferring glutamate receptors. | Wong, LA. and Mayer, ML. 1993. Mol Pharmacol. 44: 504-10. PMID: 7690448
- Inhibition by cyclothiazide of neuronal nicotinic responses in bovine chromaffin cells. | Nooney, JM. and Feltz, A. 1995. Br J Pharmacol. 114: 648-55. PMID: 7735691
- Cyclothiazide differentially modulates desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants. | Partin, KM., et al. 1994. Mol Pharmacol. 46: 129-38. PMID: 8058047
- Modulation of AMPA/kainate receptors by cyclothiazide increases cytoplasmic free Ca2+ and 45Ca2+ uptake in brain neurons. | Cebers, G. and Liljequist, S. 1995. Eur J Pharmacol. 290: 105-15. PMID: 8575524
Inhibitor of:
AMPA 3, CNIH, CNIH3, GABA Receptor, and LRRTM3.Activator of:
AMPA 1, AMPA 2, AMPA 3, AMPA 4, CNIH2, EG632778, GluR-1, GluR-2, GRIN1, GRIP2, GSG1L, Gtlf3b, mGluR-6, NETO1, NMDAζ1, NR3B, SAPAP1, and SHISA9.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cyclothiazide, 10 mg | sc-202560 | 10 mg | $107.00 | |||
Cyclothiazide, 50 mg | sc-202560A | 50 mg | $227.00 |