NOD9 Activators
NOD9 Activators are compounds that, while not directly activating NOD9 (NLRX1), can influence its activity indirectly. These compounds primarily affect cellular stress responses or the innate immune response, thereby potentially influencing the function of NLRX1. For instance, Lipopolysaccharides (LPS), TNF-alpha, and Poly(I:C) are potent activators of the innate immune response, triggering multiple signaling cascades, including the NF-κB and MAPK pathways. As NLRX1 can modulate these pathways, these compounds can indirectly activate NLRX1.
Conversely, compounds like Etoposide, Resveratrol, Rotenone, CCCP, Rapamycin, Brefeldin A, Thapsigargin, Tunicamycin, and MG-132 induce various forms of cellular stress, including DNA damage, mitochondrial dysfunction, inhibition of protein transport, endoplasmic reticulum stress, and proteasome inhibition
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide induces DNA damage and triggers the DNA damage response pathway. Given NLRX1's role in the innate immune response, this could lead to its activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to influence mitochondrial function and has anti-inflammatory effects. As NLRX1 is associated with mitochondria, this can potentially lead to its activation. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone inhibits mitochondrial electron transport, which can trigger a cellular stress response. Given NLRX1's association with mitochondria, this can potentially activate it. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $77.00 $153.00 $240.00 | 8 | |
CCCP uncouples mitochondrial oxidative phosphorylation, which can disrupt mitochondrial function and trigger a cellular stress response. This could potentially activate NLRX1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a central regulator of cell growth and proliferation. This can trigger a cellular stress response and potentially activate NLRX1. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts protein transport from the endoplasmic reticulum to the Golgi apparatus. This can trigger cellular stress responses and potentially activate NLRX1. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin induces endoplic reticulum stress by inhibiting the SERCA pump. This could potentially lead to NLRX1 activation. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, triggering endoplasmic reticulum stress. This could potentially activate NLRX1. | ||||||
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | 42424-50-0 | sc-204854 sc-204854A | 10 mg 100 mg | $139.00 $663.00 | 2 | |
Poly(I:C) is a synthetic analog of double-stranded RNA. It's a potent activator of the innate immune response and could potentially activate NLRX1. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that can trigger cellular stress responses. This could potentially activate NLRX1. | ||||||