NOD2 Activators
Common NOD2 Activators include, but are not limited to Cholecalciferol CAS 67-97-0, Lipopolysaccharide, E. coli O55:B5 CAS 93572-42-0, Butyric acid CAS 107-92-6, Curcumin CAS 458-37-7 and 3,3'-Diindolylmethane CAS 1968-05-4.
NOD2 (Nucleotide-binding oligomerization domain-containing protein 2) is a protein involved in the immune response to intracellular bacterial components, particularly muramyl dipeptide (MDP) from bacterial peptidoglycan. Dysregulation of NOD2 is associated with certain diseases, such as Crohn's disease. NOD2 activators belong to a class of chemical compounds that interact with the Nucleotide-binding Oligomerization Domain-containing protein 2 (NOD2), a critical component of the innate immune system. NOD2 is a cytoplasmic pattern recognition receptor (PRR) that plays a pivotal role in detecting and responding to bacterial components, particularly the cell wall component known as muramyl dipeptide (MDP). When NOD2 recognizes MDP, it triggers a signaling cascade that leads to the activation of immune responses, including the production of inflammatory cytokines and antimicrobial peptides. These responses are essential for the host's defense against bacterial infections, as they help to eliminate the invading pathogens and restore tissue homeostasis.
NOD2 activators are compounds designed to modulate the activity of NOD2, either by enhancing or inhibiting its signaling pathways. This modulation can have significant implications for the immune response to bacterial infections and inflammation. Enhancing NOD2 activation can lead to a more robust immune response against bacterial invaders, which is particularly important in situations where the immune system needs reinforcement. Research into NOD2 activators is part of a broader effort to understand the intricate mechanisms of the immune system's response to infections and inflammation.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 and its active form, calcitriol, can modulate immune responses. It has been shown to increase NOD2 expression in certain cell types. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
A component of gram-negative bacterial cell walls. LPS can upregulate NOD2 expression as part of the innate immune response. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $64.00 $177.00 | ||
A short-chain fatty acid produced by gut microbes. Butyrate has been shown to increase NOD2 expression in intestinal epithelial cells. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A compound found in turmeric, curcumin has anti-inflammatory properties and has been studied for its potential effects on NOD2 expression. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Primarily an anti-diabetic suggested compound, metformin has been shown to influence various cellular pathways, including those related to inflammation. It might indirectly affect NOD2 expression. | ||||||
3,3′-Diindolylmethane | 1968-05-4 | sc-204624 sc-204624A sc-204624B sc-204624C sc-204624D sc-204624E | 100 mg 500 mg 5 g 10 g 50 g 1 g | $37.00 $65.00 $89.00 $421.00 $681.00 $66.00 | 8 | |
A compound found in the digestion of indole-3-carbinol, found in cruciferous vegetables. DIM has been studied for its effects on NOD2 in the context of anti-inflammatory responses. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
The active component of chili peppers. Capsaicin has been shown to influence various cellular pathways and might affect NOD2 expression indirectly. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
An immunosuppressive suggested compound that might influence NOD2 expression indirectly through its effects on T-cell activation and other immunological pathways. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
An immunosuppressive suggested compound similar to cyclosporine A. It can influence various immune pathways and might have an indirect effect on NOD2 expression. | ||||||
6-Formylindolo[3,2-b]carbazole | 172922-91-7 | sc-300019A sc-300019 | 100 µg 5 mg | $105.00 $2185.00 | 5 | |
AhR agonist opening NOD2 chromatin structure for enhanced Sp1/Sp3 transcription factor access. | ||||||