NLRC5 Activators
NLRC5 activators are a class of chemical compounds that interact with the nucleotide-binding domain, leucine-rich repeat-containing family, CARD domain-containing 5 (NLRC5), a protein that plays a pivotal role in the regulation of immune responses. These activators can influence the activity of NLRC5, which is primarily known for its involvement in the innate immune system, particularly in the regulation of major histocompatibility complex (MHC) class I genes. NLRC5 activators function by modulating the protein's activity, which may include enhancing its stability, promoting its interaction with other molecules within the cell, or influencing its transcriptional activity. These compounds vary widely in their structure and activity but are unified by their ability to affect NLRC5, either directly by binding to the protein or indirectly by altering cellular signaling pathways that impact NLRC5 function.
The mechanisms by which NLRC5 activators exert their effects are diverse and can depend on a multitude of factors, including the cellular environment, the presence of other signaling molecules, and the specific chemical properties of the activator itself. Some of these activators may work by stabilizing NLRC5 or its degradation, thus maintaining its active state within the cell. Others might enhance the transcriptional activity of NLRC5, leading to an upregulation of genes that are under its control. Additionally, certain NLRC5 activators might modulate the protein's interaction with other cellular components, thereby influencing its role in immune signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can activate the NF-κB pathway by modulating oxidative stress and cytokine production. By enhancing NF-κB signaling, curcumin can indirectly enhance NLRC5 activity, as NF-κB is involved in the regulation of immune responses that NLRC5 is a part of. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, which is involved in the cellular response to oxidative stress. Activation of Nrf2 can lead to an upregulation of cytoprotective genes, potentially influencing the activity of NLRC5 by promoting a cellular environment that supports its function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to modulate multiple signaling pathways, including the activation of SIRT1. Through its action on SIRT1, resveratrol may enhance NLRC5 by affecting the cellular pathways associated with inflammation and immune response. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $41.00 | 4 | |
Aspirin can lead to the inhibition of COX enzymes and the modulation of the NF-κB pathway. By affecting NF-κB signaling, aspirin may indirectly enhance the functional activity of NLRC5, which is involved in immune surveillance. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $25.00 $80.00 $136.00 | 8 | |
Sodium salicylate can inhibit NF-κB activation by blocking the degradation of its inhibitor IκB. Through the modulation of NF-κB signaling, sodium salicylate could enhance the activity of NLRC5 in immune response regulation. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin can activate TRPV1 channels, leading to a cascade of events that may include the modulation of NF-κB signaling. This indirect action has the potential to enhance the activity of NLRC5 by influencing the signaling pathways it is part of. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a glucocorticoid that can modulate anti-inflammatory gene expression and inhibit NF-κB signaling. Through these actions, it may indirectly enhance NLRC5 activity by affecting the immunological environment in which NLRC5 functions. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is known to have antioxidant properties and can modulate the NF-κB and PI3K/Akt pathways. By influencing these pathways, quercetin can indirectly enhance NLRC5 function in the context of immune regulation. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
Indomethacin inhibits COX enzymes, leading to a reduction in prostaglandin synthesis. This inhibition can affect NF-κB signaling, potentially enhancing NLRC5 activity due to its role in immune processes. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3 through its active metabolite can modulate immune responses by affecting the expression of various genes, including those involved in MHC class I presentation, which can enhance the activity of NLRC5. | ||||||