NLRC5 Antibody (B-10): sc-515668

NLRC5 Antibody (B-10) is a mouse monoclonal IgM kappa light chain antibody that detects NLRC5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-NLRC5 antibody (B-10) is available as the non-conjugated form. NLRC5, also known as NOD4 or NOD27, is a crucial 1,866 amino acid cytoplasmic protein that plays a significant role in regulating NF-kappa-B and type I/II interferon signaling pathways, essential for immune response and inflammation. NLRC5 contains one NACHT domain and 26 leucine-rich repeats (LRRs), structural motifs that facilitate protein-protein interactions and contribute to regulatory functions. These LRRs, which form a hydrophobic α/β horseshoe fold, are vital for recognizing and binding to various ligands, thereby influencing innate immunity and antiviral defense mechanisms. NLRC5 is expressed in several tissues, including brain, lung, thymus, heart, spleen, and prostate, and exists as six alternatively spliced isoforms, highlighting diverse functional roles in different biological contexts. NLRC5 gene is located on human chromosome 16, underscoring importance in genetic studies related to immune responses and potential therapeutic targets.

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NLRC5 Antibody (B-10) References:

1. The leucine-rich repeat as a protein recognition motif.  |  Kobe, B. and Kajava, AV. 2001. Curr Opin Struct Biol. 11: 725-32. PMID: 11751054
2. Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product.  |  Dowds, TA., et al. 2003. Biochem Biophys Res Commun. 302: 575-80. PMID: 12615073
3. Structural analysis of leucine-rich-repeat variants in proteins associated with human diseases.  |  Matsushima, N., et al. 2005. Cell Mol Life Sci. 62: 2771-91. PMID: 16231091
4. Constitutive and UV-B modulated transcription of Nod-like receptors and their functional partners in human corneal epithelial cells.  |  Benko, S., et al. 2008. Mol Vis. 14: 1575-83. PMID: 18769647
5. The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses.  |  Kuenzel, S., et al. 2010. J Immunol. 184: 1990-2000. PMID: 20061403
6. NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.  |  Cui, J., et al. 2010. Cell. 141: 483-96. PMID: 20434986
7. NLRC5: A paradigm for NLRs in immunological and inflammatory reaction.  |  Wu, Y., et al. 2019. Cancer Lett. 451: 92-99. PMID: 30867141
8. PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity.  |  Kim, H., et al. 2020. Sci Transl Med. 12: PMID: 32641491
9. NLRC5: A Potential Target for Central Nervous System Disorders.  |  Zhang, L., et al. 2021. Front Immunol. 12: 704989. PMID: 34220868
10. NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation.  |  Sundaram, B., et al. 2024. Cell. 187: 4061-4077.e17. PMID: 38878777
11. Proteins with leucine-rich repeats.  |  Kobe, B. and Deisenhofer, J. 1995. Curr Opin Struct Biol. 5: 409-16. PMID: 7583641
12. The leucine-rich repeat: a versatile binding motif.  |  Kobe, B. and Deisenhofer, J. 1994. Trends Biochem Sci. 19: 415-21. PMID: 7817399

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NLRC5 Antibody (B-10) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-NLRC5 Antibody (B-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NLRC5 Antibody (B-10) Specifications

Alternate Product Name: NLRC5

Product Clone Name: B-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 41-64

Epitope Target: NLRC5

Epitope Species: mouse

Product Reactivity/Detection: NLRC5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for NLRC5 Antibody (B-10): N/A