NKD1 Activators
NKD1 Activators are a distinctive class of chemical compounds that play a pivotal role in the modulation of Wnt signaling, a pathway crucial for various cellular processes including cell fate determination, migration, and organogenesis. These activators work intricately within the cellular framework to bolster the function of Naked Cuticle Homolog 1 (NKD1), a protein that acts as a negative feedback regulator of Wnt signaling. By enhancing NKD1 activity, these chemicals indirectly fine-tune the Wnt pathway to ensure balanced cellular responses. For instance, certain small molecules might stabilize NKD1 against proteasomal degradation, leading to an increased level of the protein available to bind Wnt receptors or Wnt-responsive transcription factors. This binding prevents overactivation of the pathway, thereby maintaining cellular homeostasis. Another mechanism by which NKD1 activators exert their effects is through the modulation of post-translational modifications of NKD1, such as phosphorylation and ubiquitination, which can affect NKD1's ability to shuttle between the cytoplasm and nucleus and bind its targets within the Wnt signaling cascade.
The specificity of NKD1 Activators is key to their functional impact as they do not indiscriminately enhance Wnt signaling but rather precisely amplify NKD1's regulatory role within this pathway. Some activators may promote the interaction between NKD1 and Dishevelled (Dvl), a cytoplasmic anchor of the Wnt pathway, which in turn the propagation of the signal to downstream effectors like β-catenin. Others might enhance the affinity of NKD1 for its effector proteins, thereby augmenting its function and ensuring the threshold level of Wnt signaling required for proper cellular function is not exceeded. By increasing NKD1's regulatory influence, these activators serve as crucial modulators of one of the most fundamental signaling pathways governing cellular dynamics. Collectively, NKD1 Activators constitute a unique category of compounds that, by bolstering the function of NKD1, ensure the fidelity of Wnt signaling, thereby playing a significant role in maintaining the intricate balance of cellular signaling networks.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid binds to retinoic acid receptors (RARs) and retinoid X receptors (RXRs), which can enhance Wnt signaling pathway activity. NKD1, being an antagonist of the Wnt pathway, would be upregulated in response to increased pathway activity to restore balance, thus enhancing its functional activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3β, leading to the stabilization of β-catenin, a key component in the Wnt signaling pathway. The enhancement of this pathway indirectly increases the activity of NKD1, as NKD1 functions to regulate this pathway's activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels, which can lead to PKA activation. PKA can then phosphorylate various proteins involved in the Wnt signaling pathway, indirectly augmenting NKD1 activity as it acts to modulate this pathway. | ||||||
Biochanin A | 491-80-5 | sc-205603 sc-205603A | 100 mg 250 mg | $75.00 $129.00 | ||
Biochanin A is an isoflavone that acts as a tyrosine kinase inhibitor. It may enhance NKD1 activity by reducing competitive tyrosine kinase signaling, which can interfere with Wnt pathway signaling components that NKD1 regulates. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that can result in the acetylation of histones associated with the NKD1 gene, leading to its enhanced transcription and increased protein levels, indirectly promoting NKD1's functional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, potentially affecting calcium-sensitive pathways that interact with the Wnt pathway, resulting in enhanced NKD1 activity as a modulator of Wnt signaling. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Bay K8644 is an L-type calcium channel agonist that increases intracellular calcium, which can affect Wnt signaling. Elevated calcium levels can modulate Wnt pathway activity, indirectly resulting in increased NKD1 function. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is a cyclin-dependent kinase inhibitor that may lead to altered cell cycle progression and affect Wnt signaling pathway components. This creates a context where NKD1 activity could be indirectly enhanced due to changes in pathway dynamics. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
BIO is a GSK-3 inhibitor similar to lithium chloride, leading to increased β-catenin levels and subsequent Wnt pathway activation. As with lithium chloride, this would indirectly enhance NKD1 activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is another histone deacetylase inhibitor that would promote acetylation and transcriptional activation of genes related to the Wnt pathway, leading to a compensatory increase in NKD1 activity. | ||||||