NHSL2 Activators
The modulation of NHSL2, a protein involved in numerous cellular processes, can be achieved through the orchestration of various signaling pathways. Activation of adenylate cyclase by specific compounds leads to an increase in the levels of cAMP, which in turn activates protein kinase A (PKA). The activation of PKA initiates a phosphorylation cascade, which can directly or indirectly lead to the functional activation of NHSL2. This cascade is further potentiated by the use of stable cAMP analogs that bypass cellular regulatory mechanisms, allowing for a prolonged PKA signal and subsequent influence on NHSL2 activity. Additionally, when PKC is activated by compounds that mimic diacylglycerol, this kinase can modulate the activity of NHSL2 or its associated regulatory proteins, resulting in enhancement of NHSL2 function.
Aside from kinase-driven pathways, the intracellular calcium concentration plays a pivotal role in NHSL2 activity. Compounds that increase the cellular calcium levels activate various calcium-dependent signaling molecules, including calmodulin-dependent kinases, which may lead to the activation of NHSL2. Inhibition of phosphatases or GSK-3β by certain inhibitors can also lead to the activation of signaling proteins that interact with NHSL2, thereby influencing its activation state. On the other hand, inhibition of phosphodiesterase enzymes results in the accumulation of cyclic nucleotides, which further activate kinases such as PKA, leading to a potential increase in NHSL2 activity.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Directly activates adenylate cyclase, increasing cAMP levels that enhance the PKA signaling pathway. This cascade can lead to the phosphorylation and activation of NHSL2, or the phosphorylation of regulatory proteins that control NHSL2 activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC), which can modulate the activity of NHSL2 through phosphorylation or alter the activity of interacting proteins, leading to the functional activation of NHSL2. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A cAMP analog that activates PKA, triggering changes in the phosphorylation status of proteins within the signaling pathway, thereby facilitating the activation of NHSL2. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Increases intracellular calcium levels, activating calcium-dependent signaling pathways like calmodulin-dependent kinase (CaMK), which may result in the activation of NHSL2. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
A beta-adrenergic agonist which raises cAMP levels, activating PKA and potentially leading to the activation of NHSL2 through phosphorylation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3β, possibly leading to the activation of proteins within the Wnt pathway that could interact with NHSL2, resulting in its activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A calcium ionophore that raises intracellular calcium levels, potentially activating calcium-dependent proteins, including NHSL2. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Inhibits protein phosphatases PP1 and PP2A, increasing phosphorylation levels of proteins that may activate NHSL2. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Selectively inhibits phosphodiesterase 4 (PDE4), elevating cAMP levels and activating PKA, which could result in NHSL2 activation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
A stable cAMP analog that activates PKA, likely affecting the phosphorylation status of NHSL2 or proteins that regulate NHSL2 activity. | ||||||