NHE-4 Activators
NHE-4 Activators are a diverse set of chemical compounds that exert their effects through varied signaling pathways to enhance the functional activity of NHE-4. Compounds such as Forskolin and Dibutyryl-cAMP elevate intracellular cAMP levels, which activates PKA and can subsequently lead to the phosphorylation and activation of NHE-4 or its associated regulatory proteins, resulting in increased ion transport. Similarly, EGCG and Genistein act as kinase inhibitors, shifting cell signaling dynamics to favor pathways that enhance NHE-4 activity, potentially increasing the protein's role in ion exchange and pH regulation. Anethole trithione indirectly affects NHE-4 by altering the electrolyte balance which could necessitate increased NHE-4 activity to maintain homeostasis, while LY294002, as a PI3K inhibitor, and PMA, as a PKC activator, modulate other signaling pathways that can result in the upregulation of NHE-4's activity.
Furthermore, Ouabain, by inhibiting the Na+/K+-ATPase, creates a cellular environment that can drive the compensatory activation of NHE-4 to restore ionic equilibrium. Sphingosine-1-phosphate influences survival signaling pathways, which could include the activation of NHE-4 to maintain pH homeostasis. Eicosapentaenoic acid, by altering membrane fluidity and lipid signaling, may enhance the activity of NHE-4 through more optimal membrane interactions. IBMX prevents the breakdown of cAMP, thus sustaining PKA activation and the subsequent enhancement of NHE-4 function. The addition of capric acid into cell membranes might alter NHE-4 activity by changing the local lipid environment, which is crucial for its function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises intracellular cAMP levels, which can activate Protein Kinase A (PKA). Activated PKA can enhance the function of NHE-4 by phosphorylating regulatory sites on the protein or proteins within the same pathway, leading to increased ion transport activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a catechin found in green tea with kinase inhibition activity. By inhibiting certain kinases, EGCG can shift cellular signaling pathways to favor those that upregulate the activity of NHE-4, thereby enhancing its ion exchange capacity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, leading to an increase in intracellular cAMP levels. Elevated cAMP can enhance NHE-4 activity through cAMP-dependent protein kinase pathways that modulate NHE-4's activity or expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is an activator of Protein Kinase C (PKC) which can phosphorylate proteins involved in the regulation of NHE-4, thereby enhancing its sodium/hydrogen exchange activity. | ||||||
Anethole trithione | 532-11-6 | sc-337530 sc-337530A | 1 g 5 g | $214.00 $627.00 | ||
Anethole trithione stimulates the secretion of salivary and digestive juices, and can indirectly increase NHE-4 activity by modulating fluid transport and electrolyte balance in epithelial tissues. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that by inhibiting PI3K can indirectly enhance NHE-4 activity as PI3K inhibition alters cellular signaling pathways that may include upregulation of NHE-4 function in ion transport. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $516.00 | |||
Ouabain is a cardiac glycoside that inhibits Na+/K+-ATPase, which can lead to intracellular sodium accumulation. This may indirectly enhance NHE-4 activity as the protein compensates to restore ionic balance across the membrane. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P is involved in cellular signaling that regulates proliferation and survival. It can influence ion transport pathways that include NHE-4, resulting in the enhancement of NHE-4's activity in maintaining cellular pH balance. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $104.00 $431.00 | ||
EPA is an omega-3 fatty acid that modulates signal transduction pathways through its effects on membrane fluidity and lipid signaling. This modulation can enhance NHE-4 activity by optimizing membrane conditions for its function. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a cell-permeable analog of cAMP that activates PKA. The activation of PKA can increase NHE-4 activity by phosphorylation of the protein or proteins in associated regulatory pathways. | ||||||