NFAT5 Inhibitors
The diverse class of NFAT5 inhibitors constitutes a robust arsenal of chemical compounds designed to intricately modulate NFAT5 activity, either directly or indirectly. These inhibitors play a pivotal role in unraveling the complex landscape of cellular processes governed by NFAT5, particularly in the realms of osmoprotection and inflammation. Two prominent direct inhibitors, NFAT Inhibitor 1 and YM-58483, offer precise control over NFAT5 activity. NFAT Inhibitor 1 targets NFAT5's nuclear translocation, while YM-58483 specifically hones in on calcium-dependent activation. These inhibitors provide researchers with the ability to finely tune NFAT5 function, shedding light on its intricate involvement in cellular responses to hypertonic conditions.
On the indirect front, a cadre of compounds including Celastrol, Torin 1, SB 203580, Curcumin, Wortmannin, Rapamycin, SP600125, SB 202190, Bay 11-7082, and PD 98059 modulate NFAT5 through influencing key signaling pathways. The modulation of JNK, mTOR, p38 MAPK, AMPK, PI3K, NF-κB, and ERK pathways indirectly alters NFAT5 activity and downstream gene expression. This indirect approach contributes significantly to our understanding of the complex regulatory networks orchestrating NFAT5-mediated cellular responses. In conclusion, the NFAT5 inhibitor class stands as a powerful and versatile toolbox for researchers delving into the intricate roles of NFAT5 in cellular responses to osmotic stress and inflammation. The combination of direct and indirect inhibitors provides a nuanced understanding of NFAT5's involvement in cellular processes, offering valuable insights into the interconnected signaling pathways that govern NFAT5-mediated responses. The precise modes of action offered by these inhibitors contribute significantly to advancing our comprehension of NFAT5 biology and open avenues for potential interventions in conditions where NFAT5 plays a crucial role.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NFAT Inhibitor | 249537-73-3 | sc-507480 | 1 mg | $620.00 | ||
NFAT Inhibitor 1 is a direct inhibitor of NFAT5, disrupting its nuclear translocation. This small molecule interferes with the calcineurin-NFAT pathway, preventing NFAT5 activation and subsequent gene expression. The inhibition of NFAT5 alters cellular osmotic balance and impacts processes regulated by NFAT5, providing insights into its role in osmoprotection and inflammation. | ||||||
CRAC Channel Inhibitor, BTP2 | 223499-30-7 | sc-221441 | 5 mg | $185.00 | 9 | |
YM-58483 is a direct inhibitor of NFAT5, targeting its nuclear translocation. As a blocker of store-operated calcium entry (SOCE), YM-58483 inhibits the calcium-dependent activation of calcineurin, thereby impeding NFAT5 activation. This inhibition disrupts NFAT5-mediated gene expression and influences cellular processes related to osmotic stress, providing a pharmacological tool for studying NFAT5's involvement in cellular responses to hypertonic conditions. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $155.00 | 6 | |
Celastrol is an indirect inhibitor of NFAT5 through the inhibition of the JNK pathway. As a triterpenoid compound, Celastrol suppresses JNK activation, leading to decreased NFAT5 phosphorylation. This indirect inhibition alters NFAT5 activity and its downstream gene expression, impacting cellular processes associated with osmotic balance. The modulation of NFAT5 by Celastrol provides insights into the intricate crosstalk between the JNK pathway and NFAT5-mediated cellular responses. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
Torin 1 is an indirect inhibitor of NFAT5 through mTOR inhibition. As an ATP-competitive mTOR inhibitor, Torin 1 disrupts mTOR signaling, leading to decreased NFAT5 expression and activity. This indirect modulation affects cellular processes associated with osmotic stress and inflammation, providing a valuable tool for investigating the interconnected regulatory networks governing NFAT5-mediated responses. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 is an indirect inhibitor of NFAT5 through p38 MAPK inhibition. As a selective p38 MAPK inhibitor, SB 203580 interferes with the activation of p38 MAPK, leading to decreased NFAT5 phosphorylation. This indirect modulation alters NFAT5 activity and its downstream gene expression, impacting cellular processes related to osmotic stress. The use of SB 203580 offers insights into the regulatory mechanisms connecting the p38 MAPK pathway and NFAT5-mediated cellular responses. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is an indirect inhibitor of NFAT5 through AMPK activation. As a polyphenol, Curcumin activates AMP-activated protein kinase (AMPK), leading to decreased NFAT5 expression and activity. This indirect modulation influences cellular processes associated with osmotic stress, providing a pharmacological tool for studying the intricate interplay between AMPK activation and NFAT5-mediated cellular responses. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is an indirect inhibitor of NFAT5 through PI3K inhibition. As a potent PI3K inhibitor, Wortmannin disrupts PI3K signaling, leading to decreased NFAT5 expression and activity. This indirect modulation impacts cellular processes related to osmotic stress, providing a valuable tool for investigating the interconnected regulatory networks governing NFAT5-mediated responses. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an indirect inhibitor of NFAT5 through mTOR inhibition. As a macrolide immunosuppressant, Rapamycin disrupts mTOR signaling, leading to decreased NFAT5 expression and activity. This indirect modulation affects cellular processes associated with osmotic stress and inflammation, providing a pharmacological tool for studying the intricate interplay between mTOR inhibition and NFAT5-mediated cellular responses. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an indirect inhibitor of NFAT5 through JNK inhibition. As a selective JNK inhibitor, SP600125 interferes with JNK activation, leading to decreased NFAT5 phosphorylation. This indirect modulation alters NFAT5 activity and its downstream gene expression, impacting cellular processes related to osmotic stress. The use of SP600125 offers insights into the regulatory mechanisms connecting the JNK pathway and NFAT5-mediated cellular responses. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $30.00 $125.00 $445.00 | 45 | |
SB 202190 is an indirect inhibitor of NFAT5 through p38 MAPK inhibition. As a specific p38 MAPK inhibitor, SB 202190 interferes with the activation of p38 MAPK, leading to decreased NFAT5 phosphorylation. This indirect modulation alters NFAT5 activity and its downstream gene expression, impacting cellular processes related to osmotic stress. The use of SB 202190 provides a pharmacological tool for studying the interconnected regulatory networks governing NFAT5-mediated cellular responses. | ||||||